Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Mohammad H. Rahbar; Maureen Samms-Vaughan; Jianzhong Ma; Jan Bressler; Katherine A. Loveland; Manouchehr Hessabi; Aisha S. Dickerson; Megan L. Grove; Sydonnie Shakespeare-Pellington; Compton Beecher; Wayne McLaughlin; Eric Boerwinkle

doi:10.1016/j.rasd.2014.12.008

Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Mohammad H. Rahbar, Maureen Samms-Vaughan, Jianzhong Ma, Jan Bressler, Katherine A. Loveland, Manouchehr Hessabi, Aisha S. Dickerson, Megan L. Grove, Sydonnie Shakespeare-Pellington, Compton Beecher, Wayne McLaughlin, Eric Boerwinkle

Genetics

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21 Scopus citations

Abstract

We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2 and 8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [matched odds ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted.

Original language	English (US)
Pages (from-to)	1-9
Number of pages	9
Journal	Research in Autism Spectrum Disorders
Volume	12
DOIs	https://doi.org/10.1016/j.rasd.2014.12.008
State	Published - Apr 2015

Keywords

Autism spectrum disorder
Gene-gene interaction
Glutathione S-transferase (GST) genes
Modulating-factor
Oxidative stress

ASJC Scopus subject areas

Developmental and Educational Psychology
Clinical Psychology
Psychiatry and Mental health

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Rahbar, M. H., Samms-Vaughan, M., Ma, J., Bressler, J., Loveland, K. A., Hessabi, M., Dickerson, A. S., Grove, M. L., Shakespeare-Pellington, S., Beecher, C., McLaughlin, W., & Boerwinkle, E. (2015). Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders. Research in Autism Spectrum Disorders, 12, 1-9. https://doi.org/10.1016/j.rasd.2014.12.008

Rahbar, MH, Samms-Vaughan, M, Ma, J, Bressler, J, Loveland, KA, Hessabi, M, Dickerson, AS, Grove, ML, Shakespeare-Pellington, S, Beecher, C, McLaughlin, W & Boerwinkle, E 2015, 'Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders', Research in Autism Spectrum Disorders, vol. 12, pp. 1-9. https://doi.org/10.1016/j.rasd.2014.12.008

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abstract = "We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2 and 8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [matched odds ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted.",

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author = "Rahbar, {Mohammad H.} and Maureen Samms-Vaughan and Jianzhong Ma and Jan Bressler and Loveland, {Katherine A.} and Manouchehr Hessabi and Dickerson, {Aisha S.} and Grove, {Megan L.} and Sydonnie Shakespeare-Pellington and Compton Beecher and Wayne McLaughlin and Eric Boerwinkle",

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AU - Bressler, Jan

AU - Loveland, Katherine A.

AU - Hessabi, Manouchehr

AU - Dickerson, Aisha S.

AU - Grove, Megan L.

AU - Shakespeare-Pellington, Sydonnie

AU - Beecher, Compton

AU - McLaughlin, Wayne

AU - Boerwinkle, Eric

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Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Abstract

Keywords

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