TY - JOUR
T1 - Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis
AU - Liu, Xiang
AU - Yi, Chunhui
AU - Wen, Yunfei
AU - Radhakrishnan, Prakash
AU - Tremayne, Jarrod R.
AU - Dao, Thongtan
AU - Johnson, Keith R.
AU - Hollingsworth, Michael A.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - The mechanisms by which MUC1 and p120 catenin contribute to progression of cancers from early transformation to metastasis are poorly understood. Here we show that p120 catenin ARM domains 1, 3-5, and 8 mediate interactions between p120 catenin and MUC1, and that these interactions modulate dynamic properties of cell adhesion, motility, and metastasis of pancreatic cancer cells. We also show that different isoforms of p120 catenin, when coexpressed with MUC1, create cells that exhibit distinct patterns of motility in culture (motility independent of cell adhesion, motility within a monolayer while exchanging contacts with other cells, and unified motility while maintaining static epithelial contacts) and patterns of metastasis. The results provide new insight into the dynamic interplay between cell adhesion and motility and the relationship of these to the metastatic process.
AB - The mechanisms by which MUC1 and p120 catenin contribute to progression of cancers from early transformation to metastasis are poorly understood. Here we show that p120 catenin ARM domains 1, 3-5, and 8 mediate interactions between p120 catenin and MUC1, and that these interactions modulate dynamic properties of cell adhesion, motility, and metastasis of pancreatic cancer cells. We also show that different isoforms of p120 catenin, when coexpressed with MUC1, create cells that exhibit distinct patterns of motility in culture (motility independent of cell adhesion, motility within a monolayer while exchanging contacts with other cells, and unified motility while maintaining static epithelial contacts) and patterns of metastasis. The results provide new insight into the dynamic interplay between cell adhesion and motility and the relationship of these to the metastatic process.
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U2 - 10.1158/0008-5472.CAN-13-2444
DO - 10.1158/0008-5472.CAN-13-2444
M3 - Article
C2 - 24371222
AN - SCOPUS:84896501324
SN - 0008-5472
VL - 74
SP - 1609
EP - 1620
JO - Cancer Research
JF - Cancer Research
IS - 5
ER -