TY - JOUR
T1 - Interactions of metal - Metal-bonded antitumor active complexes with DNA fragments and DNA
AU - Chifotides, Helen T.
AU - Dunbar, Kim R.
PY - 2005/2
Y1 - 2005/2
N2 - This Account summarizes the DNA binding properties of anticancer active dinuclear Rh, Re, and Ru compounds. The combined results of NMR spectroscopy, X-ray crystallography, and various biochemical tools provide incontrovertible evidence that dinuclear complexes are favorably poised to bind to purine nucleobases, DNA fragments, and double-stranded DNA. Moreover, direct DNA photocleavage in vitro is effected by dirhodium compounds in the presence of electron acceptors in solution or directly attached to the dirhodium core. This research has provided valuable insight in the interactions of dinuclear compounds with DNA, knowledge that is an excellent backdrop for rational design of promising dinuclear drugs.
AB - This Account summarizes the DNA binding properties of anticancer active dinuclear Rh, Re, and Ru compounds. The combined results of NMR spectroscopy, X-ray crystallography, and various biochemical tools provide incontrovertible evidence that dinuclear complexes are favorably poised to bind to purine nucleobases, DNA fragments, and double-stranded DNA. Moreover, direct DNA photocleavage in vitro is effected by dirhodium compounds in the presence of electron acceptors in solution or directly attached to the dirhodium core. This research has provided valuable insight in the interactions of dinuclear compounds with DNA, knowledge that is an excellent backdrop for rational design of promising dinuclear drugs.
UR - http://www.scopus.com/inward/record.url?scp=13844322131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844322131&partnerID=8YFLogxK
U2 - 10.1021/ar0302078
DO - 10.1021/ar0302078
M3 - Review article
C2 - 15709734
AN - SCOPUS:13844322131
SN - 0001-4842
VL - 38
SP - 146
EP - 156
JO - Accounts of Chemical Research
JF - Accounts of Chemical Research
IS - 2
ER -