Abstract
The culture of HPBM in serum-containing medium induced a large accumulation of the protein cross-linking enzyme, tissue TGase. Immune IFN enhanced the expression of tissue TGase in cultured monocytes. Enzyme-inducing activity, both in normal and IFN-treated cells, was completely blocked by depleting the serum of the lipid fraction. The readdition of retinol at a physiologic concentration (1 μm) to delipidized serum completely restored the enzyme-inducing activity in cultured monocytes. Thus, serum retinoids seem to play an important regulatory role in the expression of tissue TGase gene in differentiating human monocytes.
Original language | English (US) |
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Pages (from-to) | 2053-2056 |
Number of pages | 4 |
Journal | Journal of Immunology |
Volume | 134 |
Issue number | 4 |
State | Published - 1985 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology