TY - JOUR
T1 - Interim Analysis of Attrition Rates in Palliative Care Study on Dignity Therapy
AU - Samuels, Virginia
AU - Schoppee, Tasha M.
AU - Greenlee, Amelia
AU - Gordon, Destiny
AU - Jean, Stacey
AU - Smith, Valandrea
AU - Reed, Tyra
AU - Kittelson, Sheri
AU - Quest, Tammie
AU - O’Mahony, Sean
AU - Hauser, Josh
AU - Guay, Marvin O.Delgado
AU - Rabow, Michael W.
AU - Emanuel, Linda
AU - Fitchett, George
AU - Handzo, George
AU - Chochinov, Harvey Max
AU - Yao, Yingwei
AU - Wilkie, Diana J.
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was made possible by Grant Number 1R01CA200867 from the National Institutes of Health (NIH), National Cancer Institute (NCI). The information in this article is solely the responsibility of the authors and does not necessarily represent the views of the NIH or NCI. The final peer-reviewed manuscript is subject to the National Institutes of Health Public Access Policy. The authors thank the patients and clinicians for giving of their time to advance science.
Publisher Copyright:
© The Author(s) 2021.
PY - 2021/12
Y1 - 2021/12
N2 - A routine threat to palliative care research is participants not completing studies. The purpose of this analysis was to quantify attrition rates mid-way through a palliative care study on Dignity Therapy and describe the reasons cited for attrition. Enrolled in the study were a total of 365 outpatients with cancer who were receiving outpatient specialty palliative care (mean age 66.7 ± 7.3 years, 56% female, 72% White, 22% Black, 6% other race/ethnicity). These participants completed an initial screening for cognitive status, performance status, physical distress, and spiritual distress. There were 76 eligible participants who did not complete the study (58% female, mean age 67.9 ± 7.3 years, 76% White, 17% Black, and 7% other race). Of those not completing the study, the average scores were 74.5 ± 11.7 on the Palliative Performance Scale and 28.3 ± 1.5 on the Mini-Mental Status Examination, whereas 22% had high spiritual distress scores and 45% had high physical distress scores. The most common reason for attrition was death/decline of health (47%), followed by patient withdrawal from the study (21%), and patient lost to follow-up (21%). The overall attrition rate was 24% and within the a priori projected attrition rate of 20%-30%. Considering the current historical context, this interim analysis is important because it will serve as baseline data on attrition prior to the outbreak of the COVID-19 pandemic. Future research will compare these results with attrition throughout the rest of the study, allowing analysis of the effect of the COVID-19 pandemic on the study attrition.
AB - A routine threat to palliative care research is participants not completing studies. The purpose of this analysis was to quantify attrition rates mid-way through a palliative care study on Dignity Therapy and describe the reasons cited for attrition. Enrolled in the study were a total of 365 outpatients with cancer who were receiving outpatient specialty palliative care (mean age 66.7 ± 7.3 years, 56% female, 72% White, 22% Black, 6% other race/ethnicity). These participants completed an initial screening for cognitive status, performance status, physical distress, and spiritual distress. There were 76 eligible participants who did not complete the study (58% female, mean age 67.9 ± 7.3 years, 76% White, 17% Black, and 7% other race). Of those not completing the study, the average scores were 74.5 ± 11.7 on the Palliative Performance Scale and 28.3 ± 1.5 on the Mini-Mental Status Examination, whereas 22% had high spiritual distress scores and 45% had high physical distress scores. The most common reason for attrition was death/decline of health (47%), followed by patient withdrawal from the study (21%), and patient lost to follow-up (21%). The overall attrition rate was 24% and within the a priori projected attrition rate of 20%-30%. Considering the current historical context, this interim analysis is important because it will serve as baseline data on attrition prior to the outbreak of the COVID-19 pandemic. Future research will compare these results with attrition throughout the rest of the study, allowing analysis of the effect of the COVID-19 pandemic on the study attrition.
KW - attrition
KW - cancer
KW - dignity therapy
KW - palliative care
KW - spirituality
UR - http://www.scopus.com/inward/record.url?scp=85100997912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100997912&partnerID=8YFLogxK
U2 - 10.1177/1049909121994309
DO - 10.1177/1049909121994309
M3 - Article
C2 - 33557587
AN - SCOPUS:85100997912
SN - 1049-9091
VL - 38
SP - 1503
EP - 1508
JO - American Journal of Hospice and Palliative Medicine
JF - American Journal of Hospice and Palliative Medicine
IS - 12
ER -