Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor α in mice

Rose Marie Bluthé; Robert Dantzer; Keith W. Kelley

doi:10.1016/0014-2999(91)90184-R

Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor α in mice

Rose Marie Bluthé, Robert Dantzer, Keith W. Kelley

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Recombinant human tumor necrosis factor α (TNFα) decreases social exploration and induces weight loss in mice in a dose- and time-dependent manner (2.5-40 μg/mouse). To assess the role of interleukin-1 (IL-1) in these effects, mice pretreated with IL-1 receptor antagonist (IL-1ra, 500 μg/mouse, i.p.) were injected with 25 μg TNFα. Pretreatment with IL-1ra antagonized the depressive effects of TNFα on behaviour but only partially attenuated the weight loss induced by this cytokine. These results suggest that TNFα-induced sickness behaviour is mediated mainly by endogenously released IL-1 whereas metabolic changes are dependent on the release of other additional cytokines.

Original language	English (US)
Pages (from-to)	281-283
Number of pages	3
Journal	European Journal of Pharmacology
Volume	209
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(91)90184-R
State	Published - Dec 17 1991
Externally published	Yes

Keywords

(Mouse)
Body weight
Interleukin-1
Interleukin-1 receptor antagonists
Social behaviour
Tumor necrosis factor

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(91)90184-R

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title = "Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor α in mice",

abstract = "Recombinant human tumor necrosis factor α (TNFα) decreases social exploration and induces weight loss in mice in a dose- and time-dependent manner (2.5-40 μg/mouse). To assess the role of interleukin-1 (IL-1) in these effects, mice pretreated with IL-1 receptor antagonist (IL-1ra, 500 μg/mouse, i.p.) were injected with 25 μg TNFα. Pretreatment with IL-1ra antagonized the depressive effects of TNFα on behaviour but only partially attenuated the weight loss induced by this cytokine. These results suggest that TNFα-induced sickness behaviour is mediated mainly by endogenously released IL-1 whereas metabolic changes are dependent on the release of other additional cytokines.",

keywords = "(Mouse), Body weight, Interleukin-1, Interleukin-1 receptor antagonists, Social behaviour, Tumor necrosis factor",

author = "Bluth{\'e}, {Rose Marie} and Robert Dantzer and Kelley, {Keith W.}",

note = "Funding Information: Many thanks are due to Dr. M. Bienkowski (Upjohn, Kalamazoo, MI) for supplying TNFo~ and to Dr. J. Vannice (Synergen, Boulder, CO) for the supply of IL-lra and his useful comments on the manuscript. We thank Dr. D. Branellec (Institut Gustave Roussy) for determining the specific activity of rTNF and Laurence Colonna-Cesari for technical assistance. This work was supported by a Grant from DRET (No. 90-166, RD).",

year = "1991",

month = dec,

day = "17",

doi = "10.1016/0014-2999(91)90184-R",

language = "English (US)",

volume = "209",

pages = "281--283",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "3",

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TY - JOUR

T1 - Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor α in mice

AU - Bluthé, Rose Marie

AU - Dantzer, Robert

AU - Kelley, Keith W.

N1 - Funding Information: Many thanks are due to Dr. M. Bienkowski (Upjohn, Kalamazoo, MI) for supplying TNFo~ and to Dr. J. Vannice (Synergen, Boulder, CO) for the supply of IL-lra and his useful comments on the manuscript. We thank Dr. D. Branellec (Institut Gustave Roussy) for determining the specific activity of rTNF and Laurence Colonna-Cesari for technical assistance. This work was supported by a Grant from DRET (No. 90-166, RD).

PY - 1991/12/17

Y1 - 1991/12/17

N2 - Recombinant human tumor necrosis factor α (TNFα) decreases social exploration and induces weight loss in mice in a dose- and time-dependent manner (2.5-40 μg/mouse). To assess the role of interleukin-1 (IL-1) in these effects, mice pretreated with IL-1 receptor antagonist (IL-1ra, 500 μg/mouse, i.p.) were injected with 25 μg TNFα. Pretreatment with IL-1ra antagonized the depressive effects of TNFα on behaviour but only partially attenuated the weight loss induced by this cytokine. These results suggest that TNFα-induced sickness behaviour is mediated mainly by endogenously released IL-1 whereas metabolic changes are dependent on the release of other additional cytokines.

AB - Recombinant human tumor necrosis factor α (TNFα) decreases social exploration and induces weight loss in mice in a dose- and time-dependent manner (2.5-40 μg/mouse). To assess the role of interleukin-1 (IL-1) in these effects, mice pretreated with IL-1 receptor antagonist (IL-1ra, 500 μg/mouse, i.p.) were injected with 25 μg TNFα. Pretreatment with IL-1ra antagonized the depressive effects of TNFα on behaviour but only partially attenuated the weight loss induced by this cytokine. These results suggest that TNFα-induced sickness behaviour is mediated mainly by endogenously released IL-1 whereas metabolic changes are dependent on the release of other additional cytokines.

KW - (Mouse)

KW - Body weight

KW - Interleukin-1

KW - Interleukin-1 receptor antagonists

KW - Social behaviour

KW - Tumor necrosis factor

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DO - 10.1016/0014-2999(91)90184-R

M3 - Article

C2 - 1839150

AN - SCOPUS:0025750765

SN - 0014-2999

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor α in mice

Abstract

Keywords

ASJC Scopus subject areas

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