TY - JOUR
T1 - International retrospective analysis of 73 cases of invasive fusariosis treated with voriconazole
AU - Lortholary, Olivier
AU - Obenga, Gaelle
AU - Biswas, Pinaki
AU - Caillot, Denis
AU - Chachaty, Elisabeth
AU - Bienvenu, Anne Lise
AU - Cornet, Muriel
AU - Greene, John
AU - Herbrecht, Raoul
AU - Lacroix, Claire
AU - Grenouillet, Frédéric
AU - Raad, Issam
AU - Sitbon, Karine
AU - Troke, Peter
AU - Berger, Pierre
AU - Bonnin, Alain
AU - Bougnoux, Marie Elisabeth
AU - Brethon, Benoit
AU - Breton, Anne
AU - Cannas, Giovanna
AU - Dinh, Aurelien
AU - Kauffmann-Lacroix, Catherine
AU - Legrand, Faezeh
AU - Petit, Arnaud
AU - Poirot, Jean Louis
AU - Pons, Denis
AU - Raffoux, Emmanuel
AU - Ranque, Stéphane
AU - Ribaux, Patricia
AU - Vekhoff, Anne
AU - Wyplosz, Benjamin
PY - 2010/10
Y1 - 2010/10
N2 - The outcomes for 73 invasive fusariosis patients treated with voriconazole were investigated. Patients with proven (n = 67) or probable (n = 6) infections were identified from the voriconazole clinical database (n = 39) and the French National Reference Center for Mycoses and Antifungals database (n = 34). Investigator-determined success was a complete or partial response. Survival was determined from day 1 of voriconazole therapy to the last day known alive. Patients were 2 to 79 years old (median, 43 years), and 66% were male. Identified Fusarium species (62%) were F. solani, F. moniliforme, F. proliferatum, and F. oxysporum. Underlying conditions analyzed included hematopoietic stem cell transplant (HSCT; 18%), hematologic malignancy (HM; 60%), chronic immunosuppression (CI; 12%), or other condition (OC; 10%). Infection sites were brain (5%), disseminated excluding brain (67%), lungs/sinus (15%), and other (12%). Most patients (64%) were or had recently been neutropenic (<500 cells/mm3). Therapy duration was 1 to 480 days (median, 57 days), with a 47% success rate. Baseline neutropenia impacted success adversely (P ≤ 0.03). Success varied by underlying condition (HSCT, 38%; HM, 45%; CI, 44%; OC, 71%) and infection site (brain, 0%; disseminated, 45%; other, 56%; lung/sinus, 64%) (P > 0.05). Combination therapy (13 patients) was no better than treatment with voriconazole alone. Overall, 59% of the patients died (49% died of fusariosis), and 90-day survival was 42%. Site of infection influenced survival (P = 0.02). Median survival (in days) by species was as follows: F. solani, 213; F. oxysporum, 112; Fusarium spp., 101; F. proliferatum, 84; F. moniliforme, 76. We conclude that voriconazole is a therapeutic option for invasive fusariosis.
AB - The outcomes for 73 invasive fusariosis patients treated with voriconazole were investigated. Patients with proven (n = 67) or probable (n = 6) infections were identified from the voriconazole clinical database (n = 39) and the French National Reference Center for Mycoses and Antifungals database (n = 34). Investigator-determined success was a complete or partial response. Survival was determined from day 1 of voriconazole therapy to the last day known alive. Patients were 2 to 79 years old (median, 43 years), and 66% were male. Identified Fusarium species (62%) were F. solani, F. moniliforme, F. proliferatum, and F. oxysporum. Underlying conditions analyzed included hematopoietic stem cell transplant (HSCT; 18%), hematologic malignancy (HM; 60%), chronic immunosuppression (CI; 12%), or other condition (OC; 10%). Infection sites were brain (5%), disseminated excluding brain (67%), lungs/sinus (15%), and other (12%). Most patients (64%) were or had recently been neutropenic (<500 cells/mm3). Therapy duration was 1 to 480 days (median, 57 days), with a 47% success rate. Baseline neutropenia impacted success adversely (P ≤ 0.03). Success varied by underlying condition (HSCT, 38%; HM, 45%; CI, 44%; OC, 71%) and infection site (brain, 0%; disseminated, 45%; other, 56%; lung/sinus, 64%) (P > 0.05). Combination therapy (13 patients) was no better than treatment with voriconazole alone. Overall, 59% of the patients died (49% died of fusariosis), and 90-day survival was 42%. Site of infection influenced survival (P = 0.02). Median survival (in days) by species was as follows: F. solani, 213; F. oxysporum, 112; Fusarium spp., 101; F. proliferatum, 84; F. moniliforme, 76. We conclude that voriconazole is a therapeutic option for invasive fusariosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=77957334912&partnerID=8YFLogxK
U2 - 10.1128/AAC.00286-10
DO - 10.1128/AAC.00286-10
M3 - Article
C2 - 20625156
AN - SCOPUS:77957334912
SN - 0066-4804
VL - 54
SP - 4446
EP - 4450
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 10
ER -