TY - JOUR
T1 - Interpretation and Application of the Likelihood Ratio to Clinical Practice in Thoracic Oncology
AU - Ost, David E.
N1 - Publisher Copyright:
© 2021 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Likelihood ratios (LRs) are a method to evaluate diagnostic test performance and assist in clinical decision making. While sensitivity and specificity are useful for binary tests, they cannot be directly applied to tests with >2 possible test results. LRs can be used for diagnostic tests with 2 or more possible test results and are also suitable for tests with continuous results. In this paper we review the concepts of LRs and how they relate to sensitivity and specificity. Practical examples from the pulmonary literature of how LRs are used to calculate posttest disease probabilities using Bayes' theorem are provided. These include examples when there are 3 or more categorical test results that have distinct interpretations (eg, cytology results from endobronchial ultrasound) as well as continuous test results (eg, computed tomography lymph node size and probability of metastasis). We also highlight some problems, pitfalls, and misunderstandings about LRs in clinical practice. We use the example of how the Nodify XL2 test incorrectly calculates and applies LRs, which may lead to falsely low estimates of the probability of cancer in some pulmonary nodules.
AB - Likelihood ratios (LRs) are a method to evaluate diagnostic test performance and assist in clinical decision making. While sensitivity and specificity are useful for binary tests, they cannot be directly applied to tests with >2 possible test results. LRs can be used for diagnostic tests with 2 or more possible test results and are also suitable for tests with continuous results. In this paper we review the concepts of LRs and how they relate to sensitivity and specificity. Practical examples from the pulmonary literature of how LRs are used to calculate posttest disease probabilities using Bayes' theorem are provided. These include examples when there are 3 or more categorical test results that have distinct interpretations (eg, cytology results from endobronchial ultrasound) as well as continuous test results (eg, computed tomography lymph node size and probability of metastasis). We also highlight some problems, pitfalls, and misunderstandings about LRs in clinical practice. We use the example of how the Nodify XL2 test incorrectly calculates and applies LRs, which may lead to falsely low estimates of the probability of cancer in some pulmonary nodules.
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U2 - 10.1097/LBR.0000000000000788
DO - 10.1097/LBR.0000000000000788
M3 - Article
C2 - 34162800
AN - SCOPUS:85116898906
SN - 1944-6586
VL - 29
SP - 62
EP - 70
JO - Journal of Bronchology and Interventional Pulmonology
JF - Journal of Bronchology and Interventional Pulmonology
IS - 1
ER -