Interrogating Metabolism in Brain Cancer

Travis C. Salzillo; Jingzhe Hu; Linda Nguyen; Nicholas Whiting; Jaehyuk Lee; Joseph Weygand; Prasanta Dutta; Shivanand Pudakalakatti; Niki Zacharias Millward; Seth T. Gammon; Frederick F. Lang; Amy B. Heimberger; Pratip K. Bhattacharya

doi:10.1016/j.mric.2016.07.003

Interrogating Metabolism in Brain Cancer

Travis C. Salzillo, Jingzhe Hu, Linda Nguyen, Nicholas Whiting, Jaehyuk Lee, Joseph Weygand, Prasanta Dutta, Shivanand Pudakalakatti, Niki Zacharias Millward, Seth T. Gammon, Frederick F. Lang, Amy B. Heimberger, Pratip K. Bhattacharya

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved.

Original language	English (US)
Pages (from-to)	687-703
Number of pages	17
Journal	Magnetic resonance imaging clinics of North America
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.mric.2016.07.003
State	Published - Nov 1 2016

Keywords

CEST
DNP
GC/MS
Hyperpolarization
MRI
MRS
Metabolic imaging
NMR

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.mric.2016.07.003

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title = "Interrogating Metabolism in Brain Cancer",

abstract = "This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved.",

keywords = "CEST, DNP, GC/MS, Hyperpolarization, MRI, MRS, Metabolic imaging, NMR",

author = "Salzillo, {Travis C.} and Jingzhe Hu and Linda Nguyen and Nicholas Whiting and Jaehyuk Lee and Joseph Weygand and Prasanta Dutta and Shivanand Pudakalakatti and Millward, {Niki Zacharias} and Gammon, {Seth T.} and Lang, {Frederick F.} and Heimberger, {Amy B.} and Bhattacharya, {Pratip K.}",

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doi = "10.1016/j.mric.2016.07.003",

language = "English (US)",

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pages = "687--703",

journal = "Magnetic resonance imaging clinics of North America",

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AU - Salzillo, Travis C.

AU - Hu, Jingzhe

AU - Nguyen, Linda

AU - Whiting, Nicholas

AU - Lee, Jaehyuk

AU - Weygand, Joseph

AU - Dutta, Prasanta

AU - Pudakalakatti, Shivanand

AU - Millward, Niki Zacharias

AU - Gammon, Seth T.

AU - Lang, Frederick F.

AU - Heimberger, Amy B.

AU - Bhattacharya, Pratip K.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved.

AB - This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved.

KW - CEST

KW - DNP

KW - GC/MS

KW - Hyperpolarization

KW - MRI

KW - MRS

KW - Metabolic imaging

KW - NMR

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EP - 703

JO - Magnetic resonance imaging clinics of North America

JF - Magnetic resonance imaging clinics of North America

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ER -

Interrogating Metabolism in Brain Cancer

Abstract

Keywords

ASJC Scopus subject areas

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