Abstract
Understanding the dynamic nature of tumor hypoxia is vital for cancer therapy. The presence of oxygen within a tumor during radiation therapy increases the likelihood of local control. We used a novel interstitial diffuse optical probe to make real-time measurements of blood volume fraction and hemoglobin oxygen saturation within a tumor at a high temporal resolution. This device was initially characterized and benchmarked using a customized vessel designed to control hemoglobin oxygen saturation and blood volume in a solution of blood with different concentrations of an oxygen scavenger, tetrakis (hydroxymethyl) phosphonium chloride. The optical device was found to consistently monitor the changes in oxygen saturation and these changes correlated to the concentration of the oxygen scavenger added. In near-simultaneous measurements of blood volume and oxygen saturation in tumor-bearing mice, the changes in blood volume fraction and oxygen saturation measured with the interstitial diffuse optical probe were benchmarked against photoacoustic imaging system to track and compare temporal dynamics of oxygen saturation and blood volume in a patient-derived xenograft model of hypopharyngeal carcinoma. Positive correlations between our device and photoacoustic imaging in measuring blood volume and oxygen saturation were observed.
| Original language | English (US) |
|---|---|
| Article number | 015039 |
| Journal | Biomedical Physics and Engineering Express |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2020 |
| Externally published | Yes |
Keywords
- dynamic hypoxia
- hemoglobin oxygen saturation
- optical fiber spectroscopy
- real-time measurement of dynamic hypoxia
- tumor oxygen saturation
ASJC Scopus subject areas
- Biophysics
- Bioengineering
- Biomaterials
- Physiology
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging
- Computer Science Applications
- Health Informatics