TY - JOUR
T1 - Intra-hepatic cholangiocarcinoma - Frequency and demographic patterns
T2 - Thirty-year data from the M.D. Anderson Cancer Center
AU - Singal, Ashwani K.
AU - Vauthey, Jean Nicolas
AU - Grady, James J.
AU - Stroehlein, John R.
PY - 2011/7
Y1 - 2011/7
N2 - Purpose: Recent reports have shown an increase in frequency of intra-hepatic cholangiocarcinoma (IHC) with a stable or decreased frequency of extra-hepatic cholangiocarcinoma (EHC). However, data on the demographic patterns associated with this change are limited. We analyzed cases of cholangiocarcinoma (CC) with aim to study frequency and demographic patterns over time of IHC and EHC. Methods: Data were collected from MD Anderson Cancer Center Tumor Registry on CC (1978-2007) and stratified on age (<50, 50-59, 60-69, and ≥70 years), gender, ethnicity (Caucasian, African-American, Hispanic, and Other), time (1978-1987, 1988-1997, 1998-2007), and diagnosis (IHC and EHC). Chi-square tests and logistic regression were used for statistics. Results: Of 1,061 CC (445 IHC), proportion of IHC increased from 30% in 1978-1998 to 48% during 1998-2007 (P < 0.0001). Compared to EHC, IHC occurred more frequently in relatively young (age < 60 years) (21 and 27% vs. 15 and 23% in 0-49 years and 50-59 years, respectively; P = 0.003) and females (48 vs. 42%, P = 0.03). Ethnic distribution was similar. There was significant (P = 0.019) interaction between age and gender using logistic regression analysis. Conclusions: Increase in frequency of IHC occurred over time and is more frequently observed among females <60 years. These data may have implications in understanding pathogenesis of IHC.
AB - Purpose: Recent reports have shown an increase in frequency of intra-hepatic cholangiocarcinoma (IHC) with a stable or decreased frequency of extra-hepatic cholangiocarcinoma (EHC). However, data on the demographic patterns associated with this change are limited. We analyzed cases of cholangiocarcinoma (CC) with aim to study frequency and demographic patterns over time of IHC and EHC. Methods: Data were collected from MD Anderson Cancer Center Tumor Registry on CC (1978-2007) and stratified on age (<50, 50-59, 60-69, and ≥70 years), gender, ethnicity (Caucasian, African-American, Hispanic, and Other), time (1978-1987, 1988-1997, 1998-2007), and diagnosis (IHC and EHC). Chi-square tests and logistic regression were used for statistics. Results: Of 1,061 CC (445 IHC), proportion of IHC increased from 30% in 1978-1998 to 48% during 1998-2007 (P < 0.0001). Compared to EHC, IHC occurred more frequently in relatively young (age < 60 years) (21 and 27% vs. 15 and 23% in 0-49 years and 50-59 years, respectively; P = 0.003) and females (48 vs. 42%, P = 0.03). Ethnic distribution was similar. There was significant (P = 0.019) interaction between age and gender using logistic regression analysis. Conclusions: Increase in frequency of IHC occurred over time and is more frequently observed among females <60 years. These data may have implications in understanding pathogenesis of IHC.
KW - Cholangiocarcinoma
KW - Demographics
KW - Epidemiology
KW - Intra-hepatic cholangiocarcinoma
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U2 - 10.1007/s00432-010-0971-z
DO - 10.1007/s00432-010-0971-z
M3 - Article
C2 - 21207060
AN - SCOPUS:79959687181
SN - 0171-5216
VL - 137
SP - 1071
EP - 1078
JO - Journal of cancer research and clinical oncology
JF - Journal of cancer research and clinical oncology
IS - 7
ER -