Intracardiac metastases detected by 18F-FSPG PET/CT

Meaghan A. Magarik; Ronald C. Walker; Jill Gilbert; H. Charles Manning; Pierre P. Massion

doi:10.1097/RLU.0000000000001883

Intracardiac metastases detected by ¹⁸F-FSPG PET/CT

Meaghan A. Magarik, Ronald C. Walker, Jill Gilbert, H. Charles Manning, Pierre P. Massion

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

PET/CT imaging is frequently used for cancer diagnosis and restaging as metabolically active cells, including cancer, utilize glucose for proliferation. ¹⁸F-FDG is the most commonly utilized radiopharmaceutical in PET/CT imaging. Limitations of ¹⁸F-FDG imaging include intense physiologic uptake in benign tissues such as the brain and myocardium. We present a case of non-small cell lung cancer with myocardial and pericardial metastases obscured by physiologic ¹⁸F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-¹⁸F-fluoropropyl)-L-glutamate (¹⁸F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of ¹⁸F-FSPG PET/CT imaging.

Original language	English (US)
Pages (from-to)	28-30
Number of pages	3
Journal	Clinical nuclear medicine
Volume	43
Issue number	1
DOIs	https://doi.org/10.1097/RLU.0000000000001883
State	Published - Jan 1 2018
Externally published	Yes

Keywords

Glutaminolysis
Lung cancer
Lung nodule
PET/CT

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000001883

Cite this

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title = "Intracardiac metastases detected by 18F-FSPG PET/CT",

abstract = "PET/CT imaging is frequently used for cancer diagnosis and restaging as metabolically active cells, including cancer, utilize glucose for proliferation. 18F-FDG is the most commonly utilized radiopharmaceutical in PET/CT imaging. Limitations of 18F-FDG imaging include intense physiologic uptake in benign tissues such as the brain and myocardium. We present a case of non-small cell lung cancer with myocardial and pericardial metastases obscured by physiologic 18F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-18F-fluoropropyl)-L-glutamate (18F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of 18F-FSPG PET/CT imaging.",

keywords = "Glutaminolysis, Lung cancer, Lung nodule, PET/CT",

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T1 - Intracardiac metastases detected by 18F-FSPG PET/CT

AU - Magarik, Meaghan A.

AU - Walker, Ronald C.

AU - Gilbert, Jill

AU - Manning, H. Charles

AU - Massion, Pierre P.

PY - 2018/1/1

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AB - PET/CT imaging is frequently used for cancer diagnosis and restaging as metabolically active cells, including cancer, utilize glucose for proliferation. 18F-FDG is the most commonly utilized radiopharmaceutical in PET/CT imaging. Limitations of 18F-FDG imaging include intense physiologic uptake in benign tissues such as the brain and myocardium. We present a case of non-small cell lung cancer with myocardial and pericardial metastases obscured by physiologic 18F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-18F-fluoropropyl)-L-glutamate (18F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of 18F-FSPG PET/CT imaging.

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KW - Lung nodule

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