Intracellular metabolism and action of an antitumor nucleoside, 2'-C- cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC)

Atsushi Azuma; Peng Huang; Akira Matsuda; William Plunkett

doi:10.1080/07328319708006127

Intracellular metabolism and action of an antitumor nucleoside, 2'-C- cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC)

Atsushi Azuma, Peng Huang, Akira Matsuda, William Plunkett

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The mechanism of antitumor activity of 2'-C-cyano-2'-deoxy-1-β-D- arabinofuranosylcytosine (CNDAC) has been examined. Intracellular metabolism of CNDAC using human leukemia cell lines are described. Incorporation of CNDAC triphosphate into DNA and the consequence of this incorporation have been evaluated in vitro using DNA primer extension assay with purified human DNA polymerase α and defined DNA primer/templates.

Original language	English (US)
Pages (from-to)	1037-1039
Number of pages	3
Journal	Nucleosides and Nucleotides
Volume	16
Issue number	7-9
DOIs	https://doi.org/10.1080/07328319708006127
State	Published - 1997

ASJC Scopus subject areas

Biochemistry
Genetics

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10.1080/07328319708006127

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abstract = "The mechanism of antitumor activity of 2'-C-cyano-2'-deoxy-1-β-D- arabinofuranosylcytosine (CNDAC) has been examined. Intracellular metabolism of CNDAC using human leukemia cell lines are described. Incorporation of CNDAC triphosphate into DNA and the consequence of this incorporation have been evaluated in vitro using DNA primer extension assay with purified human DNA polymerase α and defined DNA primer/templates.",

author = "Atsushi Azuma and Peng Huang and Akira Matsuda and William Plunkett",

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AU - Azuma, Atsushi

AU - Huang, Peng

AU - Matsuda, Akira

AU - Plunkett, William

PY - 1997

Y1 - 1997

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AB - The mechanism of antitumor activity of 2'-C-cyano-2'-deoxy-1-β-D- arabinofuranosylcytosine (CNDAC) has been examined. Intracellular metabolism of CNDAC using human leukemia cell lines are described. Incorporation of CNDAC triphosphate into DNA and the consequence of this incorporation have been evaluated in vitro using DNA primer extension assay with purified human DNA polymerase α and defined DNA primer/templates.

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Intracellular metabolism and action of an antitumor nucleoside, 2'-C- cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC)

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