TY - JOUR
T1 - Intracranial hemangiopericytoma
T2 - Patterns of failure and the role of radiation therapy
AU - Ghia, Amol J.
AU - Chang, Eric L.
AU - Allen, Pamela K.
AU - Mahajan, Anita
AU - Penas-Prado, Marta
AU - McCutcheon, Ian E.
AU - Brown, Paul D.
PY - 2013/10
Y1 - 2013/10
N2 - BACKGROUND:: Meningeal hemangiopericytoma (M-HPC) is a rare entity. OBJECTIVE:: To characterize our institutional experience in treating M-HPC. METHODS:: We reviewed the medical records of patients with M-HPC evaluated at The University of Texas M.D. Anderson Cancer Center between 1979 and 2009. RESULTS:: We identified 63 patients diagnosed between 1979 and 2009 with M-HPC treated with surgery alone or with postoperative radiotherapy (PORT). The majority were male (59%) and with a median age of 40.9 years (range, 0-71). Gross total resection (GTR) predominated (n = 31, 49%) followed by subtotal resection (n = 23, 37%) and unknown status (n = 9, 14.3%). PORT was delivered to 39 of the 63 patients (62%). The 5-, 10-, and 15-year overall survival were 90%, 68%, and 28%, respectively. The 5-, 10-, and 15-year local control (LC) were 70%, 37%, and 20%, respectively. The 5-, 10-, and 15-year metastasis-free survival were 85%, 39%, and 7%. PORT resulted in improved LC (hazard ratio [HR] 0.38, P = .008). Radiotherapy (RT) dose ≥60 Gy correlated with improved LC relative to <60 Gy (HR 0.12, P = .045). GTR correlated with improved LC (HR 0.40, P = .03). On multivariate analysis, PORT (HR 0.33, P = .003), GTR (HR = 0.33, P = .008), and RT dose ≥60 Gy (HR 0.33, P = .003) correlated with improved LC. Among those with GTR, PORT resulted in improved LC (HR 0.18, P = .027). Extent of resection and PORT did not correlate with improved overall survival. CONCLUSION:: In M-HPC, both PORT and GTR independently correlate with improved LC. PORT improves LC following GTR. We recommend RT dose ≥60 Gy to optimize LC.
AB - BACKGROUND:: Meningeal hemangiopericytoma (M-HPC) is a rare entity. OBJECTIVE:: To characterize our institutional experience in treating M-HPC. METHODS:: We reviewed the medical records of patients with M-HPC evaluated at The University of Texas M.D. Anderson Cancer Center between 1979 and 2009. RESULTS:: We identified 63 patients diagnosed between 1979 and 2009 with M-HPC treated with surgery alone or with postoperative radiotherapy (PORT). The majority were male (59%) and with a median age of 40.9 years (range, 0-71). Gross total resection (GTR) predominated (n = 31, 49%) followed by subtotal resection (n = 23, 37%) and unknown status (n = 9, 14.3%). PORT was delivered to 39 of the 63 patients (62%). The 5-, 10-, and 15-year overall survival were 90%, 68%, and 28%, respectively. The 5-, 10-, and 15-year local control (LC) were 70%, 37%, and 20%, respectively. The 5-, 10-, and 15-year metastasis-free survival were 85%, 39%, and 7%. PORT resulted in improved LC (hazard ratio [HR] 0.38, P = .008). Radiotherapy (RT) dose ≥60 Gy correlated with improved LC relative to <60 Gy (HR 0.12, P = .045). GTR correlated with improved LC (HR 0.40, P = .03). On multivariate analysis, PORT (HR 0.33, P = .003), GTR (HR = 0.33, P = .008), and RT dose ≥60 Gy (HR 0.33, P = .003) correlated with improved LC. Among those with GTR, PORT resulted in improved LC (HR 0.18, P = .027). Extent of resection and PORT did not correlate with improved overall survival. CONCLUSION:: In M-HPC, both PORT and GTR independently correlate with improved LC. PORT improves LC following GTR. We recommend RT dose ≥60 Gy to optimize LC.
KW - Adjuvant
KW - Dose response
KW - Hemangiopericytoma
KW - Intracranial
KW - Meningeal
KW - Patterns of failure
KW - Radiation
KW - Surgery
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UR - http://www.scopus.com/inward/citedby.url?scp=84885068115&partnerID=8YFLogxK
U2 - 10.1227/NEU.0000000000000064
DO - 10.1227/NEU.0000000000000064
M3 - Article
C2 - 23839520
AN - SCOPUS:84885068115
SN - 0148-396X
VL - 73
SP - 624
EP - 630
JO - Neurosurgery
JF - Neurosurgery
IS - 4
ER -