TY - JOUR
T1 - Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary Aspergillosis
AU - Quezada, Gerardo
AU - Koshkina, Nadezhda V.
AU - Zweidler-McKay, Patrick
AU - Zhou, Zichao
AU - Kontoyiannis, Dimitrios P.
AU - Kleinerman, Eugenie S.
PY - 2008/2
Y1 - 2008/2
N2 - We demonstrated that intranasal granulocyte-macrophage colony-stimulating factor given to immunosuppressed mice infected with pulmonary aspergillosis resulted in a sixfold reduction in the lung fungal burden compared to the result for saline-treated mice (P = 0.045). These data suggest that lung-targeted immunotherapy may be complementary to antifungal agents and may improve patient responses.
AB - We demonstrated that intranasal granulocyte-macrophage colony-stimulating factor given to immunosuppressed mice infected with pulmonary aspergillosis resulted in a sixfold reduction in the lung fungal burden compared to the result for saline-treated mice (P = 0.045). These data suggest that lung-targeted immunotherapy may be complementary to antifungal agents and may improve patient responses.
UR - http://www.scopus.com/inward/record.url?scp=38649100021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38649100021&partnerID=8YFLogxK
U2 - 10.1128/AAC.00760-07
DO - 10.1128/AAC.00760-07
M3 - Article
C2 - 17984233
AN - SCOPUS:38649100021
SN - 0066-4804
VL - 52
SP - 716
EP - 718
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 2
ER -