TY - JOUR
T1 - Intratumoral bleomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs.
AU - Cutrera, Jeffry
AU - Torrero, Marina
AU - Shiomitsu, Keijiro
AU - Mauldin, Neal
AU - Li, Shulin
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2008
Y1 - 2008
N2 - Bleomycin and Interleukin 12 have been used clinically to treat tumors; however, the co-administration of Bleomycin and Interleukin 12 followed by electroporation has not been tested clinically. In this study, dogs with spontaneous head and neck tumors were treated with one co-administration of Bleomycin and Interleukin 12 plasmid DNA followed by electroporation. The regression of the recurrent papillary tumor and the adjacent metastatic bone tumor was analyzed by multiple CT scans. The papillary tumor was completely eradicated in less than 2 weeks, and the bone tumor was not visible 23 weeks after the administration.
AB - Bleomycin and Interleukin 12 have been used clinically to treat tumors; however, the co-administration of Bleomycin and Interleukin 12 followed by electroporation has not been tested clinically. In this study, dogs with spontaneous head and neck tumors were treated with one co-administration of Bleomycin and Interleukin 12 plasmid DNA followed by electroporation. The regression of the recurrent papillary tumor and the adjacent metastatic bone tumor was analyzed by multiple CT scans. The papillary tumor was completely eradicated in less than 2 weeks, and the bone tumor was not visible 23 weeks after the administration.
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U2 - 10.1007/978-1-59745-194-9_24
DO - 10.1007/978-1-59745-194-9_24
M3 - Article
C2 - 18370210
AN - SCOPUS:44649143185
SN - 1064-3745
VL - 423
SP - 319
EP - 325
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -