Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study

Medicine & Life Sciences

• Phosphotyrosine 100%
• src Homology Domains 95%
• Dimerization 89%
• Molecular Dynamics Simulation 87%
• Binding Sites 60%
• Peptides 28%
• Drug Design 25%
• Ligands 23%
• Peptidomimetics 16%
• Phosphorylation 15%
• X Ray Crystallography 15%
• STAT3 Transcription Factor 13%
• Tyrosine 10%
• Intercellular Signaling Peptides and Proteins 9%
• Phosphotransferases 8%
• Neoplasms 7%
• Cytokines 6%
• Apoptosis 6%
• Growth 5%
• Pharmaceutical Preparations 4%