TY - JOUR
T1 - Invasive pulmonary fungal infection accompanied by severe hemoptysis in patients with hematologic diseases
T2 - A report of nine cases
AU - Qiu, Lei
AU - He, Jingsong
AU - Ye, Xiujin
AU - Xie, Wanzhuo
AU - Shi, Jimin
AU - Zheng, Weiyan
AU - Sun, Jie
AU - Zhu, Xiaoli
AU - Cai, Zhen
AU - Huang, He
AU - Lin, Maofang
PY - 2009/7
Y1 - 2009/7
N2 - Severe hemoptysis is the fatal complication of invasive pulmonary fungal infection (IPFI) in patients with hematologic diseases. This report retrospectively analyzed the clinical data of nine IPFI patients with hematologic diseases complicated with severe hemoptysis. Four in nine patients were diagnosed of proven IPFI, probable was established in two and the remaining were diagnosed of possible. Seven patients did not respond to the primary treatment, and four of them also did not respond to the salvage therapy. In these nine patients, seven presented massive hemoptysis and all died of that; other two patients presented severe hemoptysis. The result indicates that ineffective initial treatment and irregular therapy may underlie the concurrence of massive hemoptysis. The prognosis of IPFI patients with massive hemoptysis is very poor. Special attention for IPFI treatment should be prophylaxis, early management as well as sufficient and a whole course administration of effective broad-spectrum antifungal agents.
AB - Severe hemoptysis is the fatal complication of invasive pulmonary fungal infection (IPFI) in patients with hematologic diseases. This report retrospectively analyzed the clinical data of nine IPFI patients with hematologic diseases complicated with severe hemoptysis. Four in nine patients were diagnosed of proven IPFI, probable was established in two and the remaining were diagnosed of possible. Seven patients did not respond to the primary treatment, and four of them also did not respond to the salvage therapy. In these nine patients, seven presented massive hemoptysis and all died of that; other two patients presented severe hemoptysis. The result indicates that ineffective initial treatment and irregular therapy may underlie the concurrence of massive hemoptysis. The prognosis of IPFI patients with massive hemoptysis is very poor. Special attention for IPFI treatment should be prophylaxis, early management as well as sufficient and a whole course administration of effective broad-spectrum antifungal agents.
KW - Antifungal treatment
KW - Hemoptysis
KW - Invasive fungal infection
KW - Pulmonary, hematologic disease
UR - http://www.scopus.com/inward/record.url?scp=70350571250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350571250&partnerID=8YFLogxK
U2 - 10.1007/s12185-009-0335-0
DO - 10.1007/s12185-009-0335-0
M3 - Article
C2 - 19484336
AN - SCOPUS:70350571250
SN - 0925-5710
VL - 90
SP - 108
EP - 112
JO - International journal of hematology
JF - International journal of hematology
IS - 1
ER -