TY - JOUR
T1 - Involved Site Radiation Therapy in Adult Lymphomas
T2 - An Overview of International Lymphoma Radiation Oncology Group Guidelines
AU - Wirth, Andrew
AU - Mikhaeel, N. George
AU - Aleman, Berthe M.P.
AU - Pinnix, Chelsea C.
AU - Constine, Louis S.
AU - Ricardi, Umberto
AU - Illidge, Tim M.
AU - Eich, Hans Theodor
AU - Hoppe, Bradford S.
AU - Dabaja, Bouthaina
AU - Ng, Andrea K.
AU - Kirova, Youlia
AU - Berthelsen, Anne Kiil
AU - Dieckmann, Karin
AU - Yahalom, Joachim
AU - Specht, Lena
N1 - Funding Information:
Disclosures: L.S. has received (within the last 3 years) honoraria as a member of advisory boards for MSD, Takeda, and Kyowa Kirin. She has received honoraria for speaking from Takeda and has research grants from Varian and ViewRay.
Funding Information:
Disclosures: L.S. has received (within the last 3 years) honoraria as a member of advisory boards for MSD, Takeda, and Kyowa Kirin. She has received honoraria for speaking from Takeda and has research grants from Varian and ViewRay.
Publisher Copyright:
© 2020 The Author(s)
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Involved node radiation therapy for lymphoma was introduced with the aim of using the smallest effective treatment volume, individualized to the patient's disease distribution, to avoid the potentially unnecessary normal tissue exposure and toxicity risks associated with traditional involved field radiation therapy. The successful implementation of involved node radiation therapy requires optimal imaging and precise coregistration of baseline imaging with the radiation therapy planning computed tomography scan. Limitations of baseline imaging, changes in patient position, and anatomic changes after chemotherapy may make this difficult in routine practice. Involved site radiation therapy (ISRT) was introduced by the International Lymphoma Radiation Oncology Group as a slightly larger treated volume, intended to allow for commonly encountered uncertainties. In addition to imaging considerations, the optimal ISRT treatment volume also depends on disease histology, stage, nodal or extranodal location, and the type and efficacy of systemic therapy, which in turn influence the distribution of macroscopic and potential subclinical disease. This article presents a systematic overview of ISRT, updating key evidence and highlighting differences in the application of ISRT across the lymphoma clinical spectrum.
AB - Involved node radiation therapy for lymphoma was introduced with the aim of using the smallest effective treatment volume, individualized to the patient's disease distribution, to avoid the potentially unnecessary normal tissue exposure and toxicity risks associated with traditional involved field radiation therapy. The successful implementation of involved node radiation therapy requires optimal imaging and precise coregistration of baseline imaging with the radiation therapy planning computed tomography scan. Limitations of baseline imaging, changes in patient position, and anatomic changes after chemotherapy may make this difficult in routine practice. Involved site radiation therapy (ISRT) was introduced by the International Lymphoma Radiation Oncology Group as a slightly larger treated volume, intended to allow for commonly encountered uncertainties. In addition to imaging considerations, the optimal ISRT treatment volume also depends on disease histology, stage, nodal or extranodal location, and the type and efficacy of systemic therapy, which in turn influence the distribution of macroscopic and potential subclinical disease. This article presents a systematic overview of ISRT, updating key evidence and highlighting differences in the application of ISRT across the lymphoma clinical spectrum.
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U2 - 10.1016/j.ijrobp.2020.03.019
DO - 10.1016/j.ijrobp.2020.03.019
M3 - Review article
C2 - 32272184
AN - SCOPUS:85087812171
SN - 0360-3016
VL - 107
SP - 909
EP - 933
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 5
ER -