Abstract
Endothelial cells are capable of responding to fluid shear stress, but the molecular mechanism for this biological response remains largely unknown. Our studies indicate that the cell-cell adhesion site is a possible site of flow sensing. PECAM-1, a cell adhesion molecule localized to the interendothelial cell adhesion site, is tyrosine-phosphorylated when endothelial cell are exposed to physiological levels of fluid shear stress. This PECAM-1 phosphorylation initiates a signaling cascade leading to ERK activation. Here we review what is known about PECAM-1 tyrosine phosphorylation and suggest a possible role of PECAM-1 in mechanosensing by endothelial cells.
Original language | English (US) |
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Pages (from-to) | 11-17 |
Number of pages | 7 |
Journal | Cell structure and function |
Volume | 26 |
Issue number | 1 |
DOIs | |
State | Published - 2001 |
Keywords
- Cell adhesion
- Cytoskeleton
- Fluid shear stress
- Mechanosensing
- PECAM-1
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology