TY - JOUR
T1 - Is there a role for liquid biopsy in the surveillance of parathyroid carcinoma?
AU - Szabo Yamashita, Thomas
AU - Shirali, Aditya S.
AU - Meas, Salyna
AU - Sarli, Vanessa
AU - Clemente-Gutierrez, Uriel E.
AU - Chiang, Yi Ju
AU - Silva-Figueroa, Angelica
AU - Vodopivec, Danica M.
AU - Williams, Michelle
AU - Fisher, Sarah B.
AU - Graham, Paul H.
AU - Grubbs, Elizabeth G.
AU - Lucci, Anthony
AU - Busaidy, Naifa
AU - Perrier, Nancy D.
N1 - Publisher Copyright:
© 2023
PY - 2024/1
Y1 - 2024/1
N2 - Background: Parathyroid carcinoma is a rare malignancy with high recurrence rates. Liquid biopsy is a stratifying tool in disease recurrence/progression in other malignant processes. This study sought to assess the feasibility and application of liquid biopsy in parathyroid carcinoma and its impact on surveillance. Methods: Retrospective review of a prospectively maintained database of adults treated for parathyroid carcinoma at a tertiary care center (2017–2023). Demographics, clinical characteristics, and laboratory variables were collected. Circulating cell-free deoxyribonucleic acid enrichment and circulating tumor cell enumeration were obtained from serial blood samples. Results: A total of 25 patients were identified—64% were male patients, with a median age of 56 years (interquartile range 45–63). Fifty blood samples were collected postoperatively. At first, circulating tumor cell enumeration, 56% (14/25) of patients had no evidence of disease, and 32% (8/25) had distant metastasis. Median follow-up was 53 months (interquartile range 23–107). At the last follow-up, 40% (10/25) of patients were found to have distant metastasis. Serial circulating tumor cell enumeration was performed in 52% of patients, median highest circulating tumor cell was (interquartile range 1–22). Circulating cell-free deoxyribonucleic acid was assessed in 64% of patients (16/25). There was no difference in circulating tumor cells or circulating cell-free deoxyribonucleic acid between those with distant metastasis and those without distant metastasis. The most common mutation identified was TP53, present in 88% of circulating cell-free deoxyribonucleic acid samples with a mutation. Circulating cell-free deoxyribonucleic acid and parathyroid hormone levels were not found to have any association (r = −0.27, P =.39), but parathyroid hormone and circulating tumor cell had a linear relationship (r = 0.76, P <.001). Conclusion: Liquid biopsy appears to be a feasible tool in parathyroid carcinoma surveillance. The relationship between circulating cell-free deoxyribonucleic acid and parathyroid hormone levels remains unclear, and the association between circulating tumor cell enumeration and parathyroid hormone levels may be impactful. The finding that TP53 mutation is more prevalent in patients with distant metastasis may impact further management.
AB - Background: Parathyroid carcinoma is a rare malignancy with high recurrence rates. Liquid biopsy is a stratifying tool in disease recurrence/progression in other malignant processes. This study sought to assess the feasibility and application of liquid biopsy in parathyroid carcinoma and its impact on surveillance. Methods: Retrospective review of a prospectively maintained database of adults treated for parathyroid carcinoma at a tertiary care center (2017–2023). Demographics, clinical characteristics, and laboratory variables were collected. Circulating cell-free deoxyribonucleic acid enrichment and circulating tumor cell enumeration were obtained from serial blood samples. Results: A total of 25 patients were identified—64% were male patients, with a median age of 56 years (interquartile range 45–63). Fifty blood samples were collected postoperatively. At first, circulating tumor cell enumeration, 56% (14/25) of patients had no evidence of disease, and 32% (8/25) had distant metastasis. Median follow-up was 53 months (interquartile range 23–107). At the last follow-up, 40% (10/25) of patients were found to have distant metastasis. Serial circulating tumor cell enumeration was performed in 52% of patients, median highest circulating tumor cell was (interquartile range 1–22). Circulating cell-free deoxyribonucleic acid was assessed in 64% of patients (16/25). There was no difference in circulating tumor cells or circulating cell-free deoxyribonucleic acid between those with distant metastasis and those without distant metastasis. The most common mutation identified was TP53, present in 88% of circulating cell-free deoxyribonucleic acid samples with a mutation. Circulating cell-free deoxyribonucleic acid and parathyroid hormone levels were not found to have any association (r = −0.27, P =.39), but parathyroid hormone and circulating tumor cell had a linear relationship (r = 0.76, P <.001). Conclusion: Liquid biopsy appears to be a feasible tool in parathyroid carcinoma surveillance. The relationship between circulating cell-free deoxyribonucleic acid and parathyroid hormone levels remains unclear, and the association between circulating tumor cell enumeration and parathyroid hormone levels may be impactful. The finding that TP53 mutation is more prevalent in patients with distant metastasis may impact further management.
UR - http://www.scopus.com/inward/record.url?scp=85178221097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85178221097&partnerID=8YFLogxK
U2 - 10.1016/j.surg.2023.07.043
DO - 10.1016/j.surg.2023.07.043
M3 - Article
C2 - 37993289
AN - SCOPUS:85178221097
SN - 0039-6060
VL - 175
SP - 193
EP - 198
JO - Surgery (United States)
JF - Surgery (United States)
IS - 1
ER -