KRAS: The Art of Understanding a Complex Gene

Walter V. Velasco; Marco Ramos-Castaneda; Michael J. Clowers; Shanshan Deng; Seyed Javad Moghaddam

doi:10.1016/B978-0-08-102723-3.00003-2

KRAS: The Art of Understanding a Complex Gene

Walter V. Velasco, Marco Ramos-Castaneda, Michael J. Clowers, Shanshan Deng, Seyed Javad Moghaddam

Pulmonary Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Kirsten rat sarcoma viral oncogene (K-ras) is one of the most frequent mutations of non-small cell lung cancer (NSCLC), specifically lung adenocarcinoma. Historically K-ras has been a mutation of great resilience and complexity. This shifted the focus of therapies to several of its related signaling pathways and cytokines. However, due to a greater understanding of the intricacies behind this mutation a greater arsenal of therapies has become available to us in the form of direct K-ras therapy. With this cumulative knowledge, we hope to bring an end to this irrepressible mutation in the future.

Original language	English (US)
Title of host publication	Encyclopedia of Respiratory Medicine, Second Edition
Publisher	Elsevier
Pages	876-888
Number of pages	13
Volume	5
ISBN (Electronic)	9780081027240
ISBN (Print)	9780081027233
DOIs	https://doi.org/10.1016/B978-0-08-102723-3.00003-2
State	Published - Jan 1 2021

Keywords

Cytokine
Immunotherapy
K-ras
Lung cancer
Signaling pathway

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-08-102723-3.00003-2

Cite this

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abstract = "Kirsten rat sarcoma viral oncogene (K-ras) is one of the most frequent mutations of non-small cell lung cancer (NSCLC), specifically lung adenocarcinoma. Historically K-ras has been a mutation of great resilience and complexity. This shifted the focus of therapies to several of its related signaling pathways and cytokines. However, due to a greater understanding of the intricacies behind this mutation a greater arsenal of therapies has become available to us in the form of direct K-ras therapy. With this cumulative knowledge, we hope to bring an end to this irrepressible mutation in the future.",

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AU - Clowers, Michael J.

AU - Deng, Shanshan

AU - Moghaddam, Seyed Javad

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AB - Kirsten rat sarcoma viral oncogene (K-ras) is one of the most frequent mutations of non-small cell lung cancer (NSCLC), specifically lung adenocarcinoma. Historically K-ras has been a mutation of great resilience and complexity. This shifted the focus of therapies to several of its related signaling pathways and cytokines. However, due to a greater understanding of the intricacies behind this mutation a greater arsenal of therapies has become available to us in the form of direct K-ras therapy. With this cumulative knowledge, we hope to bring an end to this irrepressible mutation in the future.

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KW - Lung cancer

KW - Signaling pathway

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ER -

KRAS: The Art of Understanding a Complex Gene

Abstract

Keywords

ASJC Scopus subject areas

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