L-glutamic acid, a modulator of the physiological state of myeloid blood cells

M. V. Astapova; V. M. Lipkin; M. V. Arkhipova; S. G. Andreeva; S. M. Dranitsyna; M. I. Merkulova; R. I. Nurieva; E. V. Navolotskaya; I. A. Kostanyan

L-glutamic acid, a modulator of the physiological state of myeloid blood cells

M. V. Astapova, V. M. Lipkin, M. V. Arkhipova, S. G. Andreeva, S. M. Dranitsyna, M. I. Merkulova, R. I. Nurieva, E. V. Navolotskaya, I. A. Kostanyan

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-1β, IL-6, and TNFa were studied. It was shown that TNFa actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.

Original language	English (US)
Pages (from-to)	721-724
Number of pages	4
Journal	Russian Journal of Bioorganic Chemistry
Volume	25
Issue number	11
State	Published - Nov 1999
Externally published	Yes

Keywords

Differentiation
Expression of cytokines
HL-60 cells
K-526 cells
L-glutamic acid
Tumor necrosis factor

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

Cite this

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title = "L-glutamic acid, a modulator of the physiological state of myeloid blood cells",

abstract = "The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-1β, IL-6, and TNFa were studied. It was shown that TNFa actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.",

keywords = "Differentiation, Expression of cytokines, HL-60 cells, K-526 cells, L-glutamic acid, Tumor necrosis factor",

author = "Astapova, {M. V.} and Lipkin, {V. M.} and Arkhipova, {M. V.} and Andreeva, {S. G.} and Dranitsyna, {S. M.} and Merkulova, {M. I.} and Nurieva, {R. I.} and Navolotskaya, {E. V.} and Kostanyan, {I. A.}",

year = "1999",

month = nov,

language = "English (US)",

volume = "25",

pages = "721--724",

journal = "Russian Journal of Bioorganic Chemistry",

issn = "1068-1620",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "11",

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TY - JOUR

T1 - L-glutamic acid, a modulator of the physiological state of myeloid blood cells

AU - Astapova, M. V.

AU - Lipkin, V. M.

AU - Arkhipova, M. V.

AU - Andreeva, S. G.

AU - Dranitsyna, S. M.

AU - Merkulova, M. I.

AU - Nurieva, R. I.

AU - Navolotskaya, E. V.

AU - Kostanyan, I. A.

PY - 1999/11

Y1 - 1999/11

N2 - The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-1β, IL-6, and TNFa were studied. It was shown that TNFa actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.

AB - The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-1β, IL-6, and TNFa were studied. It was shown that TNFa actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.

KW - Differentiation

KW - Expression of cytokines

KW - HL-60 cells

KW - K-526 cells

KW - L-glutamic acid

KW - Tumor necrosis factor

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M3 - Article

AN - SCOPUS:27544471901

SN - 1068-1620

VL - 25

SP - 721

EP - 724

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

IS - 11

ER -

L-glutamic acid, a modulator of the physiological state of myeloid blood cells

Abstract

Keywords

ASJC Scopus subject areas

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