L-glutamic acid, a modulator of the physiological state of myeloid blood cells

M. V. Astapova; V. M. Lipkin; M. V. Arkhipova; S. G. Andreeva; S. M. Dranitsyna; M. I. Merkulova; R. I. Nurieva; E. V. Navolotskaya; I. A. Kostanyan

L-glutamic acid, a modulator of the physiological state of myeloid blood cells

M. V. Astapova, V. M. Lipkin, M. V. Arkhipova, S. G. Andreeva, S. M. Dranitsyna, M. I. Merkulova, R. I. Nurieva, E. V. Navolotskaya, I. A. Kostanyan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-I ß, IL-6, and TNFa were studied. It was shown that TNFa actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.

Original language	English (US)
Pages (from-to)	816-820
Number of pages	5
Journal	Bioorganicheskaya Khimiya
Volume	25
Issue number	11
State	Published - 2001
Externally published	Yes

Keywords

Differentiation
Expression of cytokines
HL-60 cells
K-526 cells
L-glutamic acid
Tumor necrosis factor

ASJC Scopus subject areas

General Medicine

Cite this

@article{adf32f2c89ea4ecf8b541c95ef255dfb,

title = "L-glutamic acid, a modulator of the physiological state of myeloid blood cells",

abstract = "The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-I {\ss}, IL-6, and TNFa were studied. It was shown that TNFa actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.",

keywords = "Differentiation, Expression of cytokines, HL-60 cells, K-526 cells, L-glutamic acid, Tumor necrosis factor",

author = "Astapova, {M. V.} and Lipkin, {V. M.} and Arkhipova, {M. V.} and Andreeva, {S. G.} and Dranitsyna, {S. M.} and Merkulova, {M. I.} and Nurieva, {R. I.} and Navolotskaya, {E. V.} and Kostanyan, {I. A.}",

year = "2001",

language = "English (US)",

volume = "25",

pages = "816--820",

journal = "Bioorganicheskaya Khimiya",

issn = "0132-3423",

publisher = "Izdatel'stvo Nauka",

number = "11",

}

TY - JOUR

T1 - L-glutamic acid, a modulator of the physiological state of myeloid blood cells

AU - Astapova, M. V.

AU - Lipkin, V. M.

AU - Arkhipova, M. V.

AU - Andreeva, S. G.

AU - Dranitsyna, S. M.

AU - Merkulova, M. I.

AU - Nurieva, R. I.

AU - Navolotskaya, E. V.

AU - Kostanyan, I. A.

PY - 2001

Y1 - 2001

N2 - The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-I ß, IL-6, and TNFa were studied. It was shown that TNFa actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.

AB - The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-I ß, IL-6, and TNFa were studied. It was shown that TNFa actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.

KW - Differentiation

KW - Expression of cytokines

KW - HL-60 cells

KW - K-526 cells

KW - L-glutamic acid

KW - Tumor necrosis factor

UR - http://www.scopus.com/inward/record.url?scp=0033222135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033222135&partnerID=8YFLogxK

M3 - Article

C2 - 10645486

AN - SCOPUS:0033222135

SN - 0132-3423

VL - 25

SP - 816

EP - 820

JO - Bioorganicheskaya Khimiya

JF - Bioorganicheskaya Khimiya

IS - 11

ER -

L-glutamic acid, a modulator of the physiological state of myeloid blood cells

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this