L-Selectin - A dynamic regulator of leukocyte migration

Stefanie Wedepohl; Figen Beceren-Braun; Sebastian Riese; Konrad Buscher; Sven Enders; Gesche Bernhard; Karin Kilian; Véronique Blanchard; Jens Dernedde; Rudolf Tauber

doi:10.1016/j.ejcb.2011.02.007

L-Selectin - A dynamic regulator of leukocyte migration

Stefanie Wedepohl, Figen Beceren-Braun, Sebastian Riese, Konrad Buscher, Sven Enders, Gesche Bernhard, Karin Kilian, Véronique Blanchard, Jens Dernedde, Rudolf Tauber

Immunology

Research output: Contribution to journal › Short survey › peer-review

60 Scopus citations

Abstract

The leukocytic cell adhesion receptor l-selectin mediates the initial step of the adhesion cascade, the capture and rolling of leukocytes on endothelial cells. This event enables leukocytes to migrate out of the vasculature into surrounding tissues during inflammation and immune surveillance. Distinct domains of l-selectin contribute to proper leukocyte migration. In this review, we discuss the contributions of these domains with respect to l-selectin function: the regulation by serine phosphorylation of the cytoplasmic tail, the role of the transmembrane domain in receptor positioning on the cell surface as well as the N-glycosylation of the extracellular part and the identification of novel binding partners.

Original language	English (US)
Pages (from-to)	257-264
Number of pages	8
Journal	European journal of cell biology
Volume	91
Issue number	4
DOIs	https://doi.org/10.1016/j.ejcb.2011.02.007
State	Published - Apr 2012

Keywords

Domain function
L-Selectin
Leukocyte migration
Ligands
Posttranslational modification

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Cell Biology

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10.1016/j.ejcb.2011.02.007

Cite this

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title = "L-Selectin - A dynamic regulator of leukocyte migration",

abstract = "The leukocytic cell adhesion receptor l-selectin mediates the initial step of the adhesion cascade, the capture and rolling of leukocytes on endothelial cells. This event enables leukocytes to migrate out of the vasculature into surrounding tissues during inflammation and immune surveillance. Distinct domains of l-selectin contribute to proper leukocyte migration. In this review, we discuss the contributions of these domains with respect to l-selectin function: the regulation by serine phosphorylation of the cytoplasmic tail, the role of the transmembrane domain in receptor positioning on the cell surface as well as the N-glycosylation of the extracellular part and the identification of novel binding partners.",

keywords = "Domain function, L-Selectin, Leukocyte migration, Ligands, Posttranslational modification",

author = "Stefanie Wedepohl and Figen Beceren-Braun and Sebastian Riese and Konrad Buscher and Sven Enders and Gesche Bernhard and Karin Kilian and V{\'e}ronique Blanchard and Jens Dernedde and Rudolf Tauber",

note = "Funding Information: This work was supported by the German Research Foundation (DFG) within the collaborative research center SFB 449.",

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doi = "10.1016/j.ejcb.2011.02.007",

language = "English (US)",

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T1 - L-Selectin - A dynamic regulator of leukocyte migration

AU - Wedepohl, Stefanie

AU - Beceren-Braun, Figen

AU - Riese, Sebastian

AU - Buscher, Konrad

AU - Enders, Sven

AU - Bernhard, Gesche

AU - Kilian, Karin

AU - Blanchard, Véronique

AU - Dernedde, Jens

AU - Tauber, Rudolf

N1 - Funding Information: This work was supported by the German Research Foundation (DFG) within the collaborative research center SFB 449.

PY - 2012/4

Y1 - 2012/4

N2 - The leukocytic cell adhesion receptor l-selectin mediates the initial step of the adhesion cascade, the capture and rolling of leukocytes on endothelial cells. This event enables leukocytes to migrate out of the vasculature into surrounding tissues during inflammation and immune surveillance. Distinct domains of l-selectin contribute to proper leukocyte migration. In this review, we discuss the contributions of these domains with respect to l-selectin function: the regulation by serine phosphorylation of the cytoplasmic tail, the role of the transmembrane domain in receptor positioning on the cell surface as well as the N-glycosylation of the extracellular part and the identification of novel binding partners.

AB - The leukocytic cell adhesion receptor l-selectin mediates the initial step of the adhesion cascade, the capture and rolling of leukocytes on endothelial cells. This event enables leukocytes to migrate out of the vasculature into surrounding tissues during inflammation and immune surveillance. Distinct domains of l-selectin contribute to proper leukocyte migration. In this review, we discuss the contributions of these domains with respect to l-selectin function: the regulation by serine phosphorylation of the cytoplasmic tail, the role of the transmembrane domain in receptor positioning on the cell surface as well as the N-glycosylation of the extracellular part and the identification of novel binding partners.

KW - Domain function

KW - L-Selectin

KW - Leukocyte migration

KW - Ligands

KW - Posttranslational modification

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EP - 264

JO - European journal of cell biology

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L-Selectin - A dynamic regulator of leukocyte migration

Abstract

Keywords

ASJC Scopus subject areas

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