Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma

Bojana Djordjevic; Russell R. Broaddus

doi:10.1016/j.path.2016.01.007

Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma

Bojana Djordjevic, Russell R. Broaddus

Pathology

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

This article reviews the main tissue testing modalities for Lynch Syndrome in the pathology laboratory, such as immunohistochemistry and PCR based analyses, and discusses their routine application, interpretation pitfalls, and troubleshooting of common technical performance issues. Discrepancies between laboratory and genetic testing may arise, and are examined in the context of the complexity of molecular abnormalities associated with Lynch Syndrome. The merits of targeted versus universal screening in a changing healthcare climate are addressed. In the absence of comprehensive screening programs, specific tumor topography and histological features that may prompt pathologist-initiated molecular tumor testing are outlined.

Original language	English (US)
Pages (from-to)	289-299
Number of pages	11
Journal	Surgical Pathology Clinics
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.path.2016.01.007
State	Published - Jun 1 2016

Keywords

Endometrial cancer
Lynch syndrome
Molecular diagnostic testing

ASJC Scopus subject areas

Surgery
Pathology and Forensic Medicine

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10.1016/j.path.2016.01.007

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title = "Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma",

abstract = "This article reviews the main tissue testing modalities for Lynch Syndrome in the pathology laboratory, such as immunohistochemistry and PCR based analyses, and discusses their routine application, interpretation pitfalls, and troubleshooting of common technical performance issues. Discrepancies between laboratory and genetic testing may arise, and are examined in the context of the complexity of molecular abnormalities associated with Lynch Syndrome. The merits of targeted versus universal screening in a changing healthcare climate are addressed. In the absence of comprehensive screening programs, specific tumor topography and histological features that may prompt pathologist-initiated molecular tumor testing are outlined.",

keywords = "Endometrial cancer, Lynch syndrome, Molecular diagnostic testing",

author = "Bojana Djordjevic and Broaddus, {Russell R.}",

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N2 - This article reviews the main tissue testing modalities for Lynch Syndrome in the pathology laboratory, such as immunohistochemistry and PCR based analyses, and discusses their routine application, interpretation pitfalls, and troubleshooting of common technical performance issues. Discrepancies between laboratory and genetic testing may arise, and are examined in the context of the complexity of molecular abnormalities associated with Lynch Syndrome. The merits of targeted versus universal screening in a changing healthcare climate are addressed. In the absence of comprehensive screening programs, specific tumor topography and histological features that may prompt pathologist-initiated molecular tumor testing are outlined.

AB - This article reviews the main tissue testing modalities for Lynch Syndrome in the pathology laboratory, such as immunohistochemistry and PCR based analyses, and discusses their routine application, interpretation pitfalls, and troubleshooting of common technical performance issues. Discrepancies between laboratory and genetic testing may arise, and are examined in the context of the complexity of molecular abnormalities associated with Lynch Syndrome. The merits of targeted versus universal screening in a changing healthcare climate are addressed. In the absence of comprehensive screening programs, specific tumor topography and histological features that may prompt pathologist-initiated molecular tumor testing are outlined.

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KW - Molecular diagnostic testing

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Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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