TY - JOUR
T1 - Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models
AU - Bertilaccio, Maria Teresa Sabrina
AU - Simonetti, Giorgia
AU - Dagklis, Antonis
AU - Rocchi, Martina
AU - Rodriguez, Tania Veliz
AU - Apollonio, Benedetta
AU - Mantovani, Alberto
AU - Ponzoni, Maurilio
AU - Ghia, Paolo
AU - Garlanda, Cecilia
AU - Caligaris-Cappio, Federico
AU - Muzio, Marta
PY - 2011/7/21
Y1 - 2011/7/21
N2 - Inflammation is involved in the initiation and progression of several chronic lymphoid malignancies of B-cell type. Tolllike receptors (TLR) are transmembrane inflammatory receptors that on recognition of pathogen-associated molecular patterns trigger an innate immune response and bridge the innate and adaptive immune response by acting as costimulatory signals for B cells. Fine tuning of TLR and IL-1R-like (ILR) activity is regulated by TIR8 (SIGIRR), a transmembrane receptor of the TLR/ILR family which inhibits other family members. To test the hypothesis that TLR and/or ILR may play a role in the natural history of chronic B-cell tumors, we crossed Eμ-TCL1 transgenic mice, a well established model of chronic lymphocytic leukemia (CLL), with mice lacking the inhibitory receptor TIR8 that allow an unabated TLR-mediated stimulation. We here report that in the absence of TIR8 the appearance of monoclonal B-cell expansions is accelerated and mouse life span is shortened. The morphology and phenotype of the mouse leukemic expansions reproduce the progression of human CLL into an aggressive and frequently terminal phase characterized by the appearance of prolymphocytes. This study reveals an important pathogenetic implication of TLR in CLL development and progression.
AB - Inflammation is involved in the initiation and progression of several chronic lymphoid malignancies of B-cell type. Tolllike receptors (TLR) are transmembrane inflammatory receptors that on recognition of pathogen-associated molecular patterns trigger an innate immune response and bridge the innate and adaptive immune response by acting as costimulatory signals for B cells. Fine tuning of TLR and IL-1R-like (ILR) activity is regulated by TIR8 (SIGIRR), a transmembrane receptor of the TLR/ILR family which inhibits other family members. To test the hypothesis that TLR and/or ILR may play a role in the natural history of chronic B-cell tumors, we crossed Eμ-TCL1 transgenic mice, a well established model of chronic lymphocytic leukemia (CLL), with mice lacking the inhibitory receptor TIR8 that allow an unabated TLR-mediated stimulation. We here report that in the absence of TIR8 the appearance of monoclonal B-cell expansions is accelerated and mouse life span is shortened. The morphology and phenotype of the mouse leukemic expansions reproduce the progression of human CLL into an aggressive and frequently terminal phase characterized by the appearance of prolymphocytes. This study reveals an important pathogenetic implication of TLR in CLL development and progression.
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U2 - 10.1182/blood-2011-01-329870
DO - 10.1182/blood-2011-01-329870
M3 - Article
C2 - 21652674
AN - SCOPUS:79960691639
SN - 0006-4971
VL - 118
SP - 660
EP - 669
JO - Blood
JF - Blood
IS - 3
ER -