TY - GEN
T1 - Large scale agent-based modeling of the humoral and cellular immune response
AU - Stracquadanio, Giovanni
AU - Umeton, Renato
AU - Costanza, Jole
AU - Annibali, Viviana
AU - Mechelli, Rosella
AU - Pavone, Mario
AU - Zammataro, Luca
AU - Nicosia, Giuseppe
PY - 2011
Y1 - 2011
N2 - The Immune System is, together with Central Nervous System, one of the most important and complex unit of our organism. Despite great advances in recent years that shed light on its understanding and in the unraveling of key mechanisms behind its functions, there are still many areas of the Immune System that remain object of active research. The development of in-silico models, bridged with proper biological considerations, have recently improved the understanding of important complex systems [1,2]. In this paper, after introducing major role players and principal functions of the mammalian Immune System, we present two computational approaches to its modeling; i.e., two in-silico Immune Systems. (i) A large-scale model, with a complexity of representation of 106 - 108 cells (e.g., APC, T, B and Plasma cells) and molecules (e.g., immunocomplexes), is here presented, and its evolution in time is shown to be mimicking an important region of a real immune response. (ii) Additionally, a viral infection model, stochastic and light-weight, is here presented as well: its seamless design from biological considerations, its modularity and its fast simulation times are strength points when compared to (i). Finally we report, with the intent of moving towards the virtual lymph note, a cost-benefits comparison among Immune System models presented in this paper.
AB - The Immune System is, together with Central Nervous System, one of the most important and complex unit of our organism. Despite great advances in recent years that shed light on its understanding and in the unraveling of key mechanisms behind its functions, there are still many areas of the Immune System that remain object of active research. The development of in-silico models, bridged with proper biological considerations, have recently improved the understanding of important complex systems [1,2]. In this paper, after introducing major role players and principal functions of the mammalian Immune System, we present two computational approaches to its modeling; i.e., two in-silico Immune Systems. (i) A large-scale model, with a complexity of representation of 106 - 108 cells (e.g., APC, T, B and Plasma cells) and molecules (e.g., immunocomplexes), is here presented, and its evolution in time is shown to be mimicking an important region of a real immune response. (ii) Additionally, a viral infection model, stochastic and light-weight, is here presented as well: its seamless design from biological considerations, its modularity and its fast simulation times are strength points when compared to (i). Finally we report, with the intent of moving towards the virtual lymph note, a cost-benefits comparison among Immune System models presented in this paper.
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U2 - 10.1007/978-3-642-22371-6_2
DO - 10.1007/978-3-642-22371-6_2
M3 - Conference contribution
AN - SCOPUS:79960346763
SN - 9783642223709
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 15
EP - 29
BT - Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings
T2 - 10th International Conference on Artificial Immune Systems, ICARIS 2011
Y2 - 18 July 2011 through 21 July 2011
ER -