Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy

Robin Jacob; Paolo Strati; Nicolas Palaskas; Juan C. Lopez-Mattei; Konstantinos Marmagkiolis; L. Maximilian Buja; Anita Deswal; Cezar Iliescu

doi:10.1016/j.jaccas.2020.07.033

Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy

Robin Jacob, Paolo Strati, Nicolas Palaskas, Juan C. Lopez-Mattei, Konstantinos Marmagkiolis, L. Maximilian Buja, Anita Deswal, Cezar Iliescu

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.)

Original language	English (US)
Pages (from-to)	2095-2100
Number of pages	6
Journal	JACC: Case Reports
Volume	2
Issue number	13
DOIs	https://doi.org/10.1016/j.jaccas.2020.07.033
State	Published - Nov 2020

Keywords

cardio-oncology
cardiotoxicity
follicular lymphoma
lenalidomide
myocarditis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jaccas.2020.07.033

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title = "Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy",

abstract = "A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.)",

keywords = "cardio-oncology, cardiotoxicity, follicular lymphoma, lenalidomide, myocarditis",

author = "Robin Jacob and Paolo Strati and Nicolas Palaskas and Lopez-Mattei, {Juan C.} and Konstantinos Marmagkiolis and Buja, {L. Maximilian} and Anita Deswal and Cezar Iliescu",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = nov,

doi = "10.1016/j.jaccas.2020.07.033",

language = "English (US)",

volume = "2",

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T1 - Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy

AU - Jacob, Robin

AU - Strati, Paolo

AU - Palaskas, Nicolas

AU - Lopez-Mattei, Juan C.

AU - Marmagkiolis, Konstantinos

AU - Buja, L. Maximilian

AU - Deswal, Anita

AU - Iliescu, Cezar

PY - 2020/11

Y1 - 2020/11

N2 - A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.)

AB - A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.)

KW - cardio-oncology

KW - cardiotoxicity

KW - follicular lymphoma

KW - lenalidomide

KW - myocarditis

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JO - JACC: Case Reports

JF - JACC: Case Reports

IS - 13

ER -

Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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