Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care

Inna Smalley; Adrienne Boire; Priscilla Brastianos; Harriet M. Kluger; Eva Hernando-Monge; Peter A. Forsyth; Kamran A. Ahmed; Keiran S.M. Smalley; Sherise Ferguson; Michael A. Davies; Isabella C. Glitza Oliva

doi:10.1111/pcmr.13116

Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care

Inna Smalley, Adrienne Boire, Priscilla Brastianos, Harriet M. Kluger, Eva Hernando-Monge, Peter A. Forsyth, Kamran A. Ahmed, Keiran S.M. Smalley, Sherise Ferguson, Michael A. Davies, Isabella C. Glitza Oliva

Research output: Contribution to journal › Review article › peer-review

Abstract

Leptomeningeal disease (LMD) remains a major challenge in the clinical management of metastatic melanoma patients. Outcomes for patient remain poor, and patients with LMD continue to be excluded from almost all clinical trials. However, recent trials have demonstrated the feasibility of conducting prospective clinical trials in these patients. Further, new insights into the pathophysiology of LMD are identifying rational new therapeutic strategies. Here we present recent advances in the understanding of, and treatment options for, LMD from metastatic melanoma. We also annotate key areas of future focus to accelerate progress for this challenging but emerging field.

Original language	English (US)
Pages (from-to)	51-67
Number of pages	17
Journal	Pigment Cell and Melanoma Research
Volume	37
Issue number	1
DOIs	https://doi.org/10.1111/pcmr.13116
State	Published - Jan 2024

Keywords

Central Nervous System Metastasis
leptomeningeal disease
melanoma

ASJC Scopus subject areas

Oncology
General Biochemistry, Genetics and Molecular Biology
Dermatology

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10.1111/pcmr.13116

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Smalley, I., Boire, A., Brastianos, P., Kluger, H. M., Hernando-Monge, E., Forsyth, P. A., Ahmed, K. A., Smalley, K. S. M., Ferguson, S., Davies, M. A., & Glitza Oliva, I. C. (2024). Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care. Pigment Cell and Melanoma Research, 37(1), 51-67. https://doi.org/10.1111/pcmr.13116

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abstract = "Leptomeningeal disease (LMD) remains a major challenge in the clinical management of metastatic melanoma patients. Outcomes for patient remain poor, and patients with LMD continue to be excluded from almost all clinical trials. However, recent trials have demonstrated the feasibility of conducting prospective clinical trials in these patients. Further, new insights into the pathophysiology of LMD are identifying rational new therapeutic strategies. Here we present recent advances in the understanding of, and treatment options for, LMD from metastatic melanoma. We also annotate key areas of future focus to accelerate progress for this challenging but emerging field.",

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AU - Smalley, Inna

AU - Boire, Adrienne

AU - Brastianos, Priscilla

AU - Kluger, Harriet M.

AU - Hernando-Monge, Eva

AU - Forsyth, Peter A.

AU - Ahmed, Kamran A.

AU - Smalley, Keiran S.M.

AU - Ferguson, Sherise

AU - Davies, Michael A.

AU - Glitza Oliva, Isabella C.

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AB - Leptomeningeal disease (LMD) remains a major challenge in the clinical management of metastatic melanoma patients. Outcomes for patient remain poor, and patients with LMD continue to be excluded from almost all clinical trials. However, recent trials have demonstrated the feasibility of conducting prospective clinical trials in these patients. Further, new insights into the pathophysiology of LMD are identifying rational new therapeutic strategies. Here we present recent advances in the understanding of, and treatment options for, LMD from metastatic melanoma. We also annotate key areas of future focus to accelerate progress for this challenging but emerging field.

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Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care

Abstract

Keywords

ASJC Scopus subject areas

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