TY - JOUR
T1 - Leukemic mantle cell lymphoma
T2 - Clinical and pathologic spectrum of twenty-three cases
AU - Schlette, Ellen
AU - Lai, Raymond
AU - Onciu, Mihaela
AU - Doherty, Dorota
AU - Bueso-Ramos, Carlos
AU - Medeiros, L. Jeffrey
PY - 2001
Y1 - 2001
N2 - Twenty-three patients with marked leukemic involvement by mantle cell lymphoma (MCL) are described. Each patient had an absolute lymphocyte count more than 10 × 109/L. The diagnosis of MCL was supported by compatible immunophenotypic findings and the t(11;14)(q13;q32) in all cases. Morphologically, these cases exhibited a spectrum of findings that we divided into two groups using a cutoff of 20% large or blastoid cells (log rank test, P = .004). Patients with small-cell (<20%) morphologic features survived longer than patients with large/blastoid (≥20%) morphologic features, (P = .003, log rank test). The most common additional karyotypic abnormality identified in this study involved chromosome 17, in 13 of 23 (56.5%) cases, which correlated with p53 overexpression but not with cytologic features. We conclude that cytologic features of MCL predict the prognosis of patients with marked leukemic involvement. Chromosome 17 abnormalities are common in leukemic MCL, may be involved in pathogenesis, and are associated with p53 expression.
AB - Twenty-three patients with marked leukemic involvement by mantle cell lymphoma (MCL) are described. Each patient had an absolute lymphocyte count more than 10 × 109/L. The diagnosis of MCL was supported by compatible immunophenotypic findings and the t(11;14)(q13;q32) in all cases. Morphologically, these cases exhibited a spectrum of findings that we divided into two groups using a cutoff of 20% large or blastoid cells (log rank test, P = .004). Patients with small-cell (<20%) morphologic features survived longer than patients with large/blastoid (≥20%) morphologic features, (P = .003, log rank test). The most common additional karyotypic abnormality identified in this study involved chromosome 17, in 13 of 23 (56.5%) cases, which correlated with p53 overexpression but not with cytologic features. We conclude that cytologic features of MCL predict the prognosis of patients with marked leukemic involvement. Chromosome 17 abnormalities are common in leukemic MCL, may be involved in pathogenesis, and are associated with p53 expression.
KW - Conventional cytogenetics
KW - Leukemia
KW - Mantle cell lymphoma
KW - t(11;14)
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U2 - 10.1038/modpathol.3880448
DO - 10.1038/modpathol.3880448
M3 - Article
C2 - 11706075
AN - SCOPUS:0035158697
SN - 0893-3952
VL - 14
SP - 1133
EP - 1140
JO - Modern Pathology
JF - Modern Pathology
IS - 11
ER -