TY - JOUR
T1 - Leukocyte telomere length and renal cell carcinoma survival in two studies
AU - Callahan, Catherine L.
AU - Schwartz, Kendra
AU - Ruterbusch, Julie J.
AU - Shuch, Brian
AU - Graubard, Barry I.
AU - Lan, Qing
AU - Cawthon, Richard
AU - Baccarelli, Andrea A.
AU - Chow, Wong Ho
AU - Rothman, Nathaniel
AU - Hofmann, Jonathan N.
AU - Purdue, Mark P.
N1 - Publisher Copyright:
© 2017 Cancer Research UK.
PY - 2017/8/22
Y1 - 2017/8/22
N2 - Background:Leukocyte telomere length (LTL) is a potential biomarker of cancer prognosis; however, evidence for renal cell carcinoma (RCC) is inconsistent.Methods:We investigated LTL and RCC-specific survival among 684 cases from the US kidney cancer study (USKC) and 241 cases from the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO). Leukocyte telomere length was measured by quantitative polymerase chain reaction, and hazard ratios (HRs) and 95% confidence intervals (CIs) computed using multivariable Cox models.Results:Short LTL was associated with poorer disease-specific survival in both USKC (lowest vs highest quartile: HR: 2.3, 95% CI: 1.2-4.4; P for trend=0.02) and PLCO (HR: 2.4, 95% CI: 1.0-5.4; P=0.04). Among USKC cases, the association was strongest for stage-I RCC (HR: 5.5, 95% CI: 1.6-19.0; P=0.006).Conclusions:Our findings suggest that shorter LTL is an independent marker of poor RCC prognosis, particularly for stage-I disease.
AB - Background:Leukocyte telomere length (LTL) is a potential biomarker of cancer prognosis; however, evidence for renal cell carcinoma (RCC) is inconsistent.Methods:We investigated LTL and RCC-specific survival among 684 cases from the US kidney cancer study (USKC) and 241 cases from the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO). Leukocyte telomere length was measured by quantitative polymerase chain reaction, and hazard ratios (HRs) and 95% confidence intervals (CIs) computed using multivariable Cox models.Results:Short LTL was associated with poorer disease-specific survival in both USKC (lowest vs highest quartile: HR: 2.3, 95% CI: 1.2-4.4; P for trend=0.02) and PLCO (HR: 2.4, 95% CI: 1.0-5.4; P=0.04). Among USKC cases, the association was strongest for stage-I RCC (HR: 5.5, 95% CI: 1.6-19.0; P=0.006).Conclusions:Our findings suggest that shorter LTL is an independent marker of poor RCC prognosis, particularly for stage-I disease.
UR - http://www.scopus.com/inward/record.url?scp=85028296529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028296529&partnerID=8YFLogxK
U2 - 10.1038/bjc.2017.237
DO - 10.1038/bjc.2017.237
M3 - Article
C2 - 28742796
AN - SCOPUS:85028296529
SN - 0007-0920
VL - 117
SP - 752
EP - 755
JO - British journal of cancer
JF - British journal of cancer
IS - 5
ER -