TY - JOUR
T1 - Light-activatable gold nanoshells for drug delivery applications
AU - Singhana, Burapol
AU - Slattery, Patrick
AU - Chen, Aaron
AU - Wallace, Michael
AU - Melancon, Marites P.
N1 - Funding Information:
The authors thank Luanne Jorewicz in MD Anderson’s Department of Scientific Publications for editing the manuscript. This work was supported in part by a grant from the John S. Dunn Foundation and by the National Institutes of Health through MD Anderson’s Cancer Center Support Grant CA016672.
PY - 2014/6
Y1 - 2014/6
N2 - Gold nanoshells (AuNSs) are currently being investigated as nanocarriers for drug delivery systems and have both diagnostic and therapeutic applications, including photothermal ablation, hyperthermia, drug delivery, and diagnostic imaging, particularly in oncology. AuNSs are valuable for their localized surface plasmon resonance, biocompatibility, low immunogenicity, and facile functionalization. AuNSs used for drug delivery can be spatially and temporally triggered to release controlled quantities of drugs inside the target cells when illuminated with a near-infrared (NIR) laser. Recently, many research groups have demonstrated that these AuNS complexes are able to deliver antitumor drugs (e.g., doxorubicin, paclitaxel, small interfering RNA, and single-stranded DNA) into cancer cells, which enhances the efficacy of treatment. AuNSs can also be functionalized with active targeting ligands such as antibodies, aptamers, and peptides to increase the particles' specific binding to the desired targets. This article reviews the current research on NIR light-activatable AuNSs used as nanocarriers for drug delivery systems and cancer theranostics.
AB - Gold nanoshells (AuNSs) are currently being investigated as nanocarriers for drug delivery systems and have both diagnostic and therapeutic applications, including photothermal ablation, hyperthermia, drug delivery, and diagnostic imaging, particularly in oncology. AuNSs are valuable for their localized surface plasmon resonance, biocompatibility, low immunogenicity, and facile functionalization. AuNSs used for drug delivery can be spatially and temporally triggered to release controlled quantities of drugs inside the target cells when illuminated with a near-infrared (NIR) laser. Recently, many research groups have demonstrated that these AuNS complexes are able to deliver antitumor drugs (e.g., doxorubicin, paclitaxel, small interfering RNA, and single-stranded DNA) into cancer cells, which enhances the efficacy of treatment. AuNSs can also be functionalized with active targeting ligands such as antibodies, aptamers, and peptides to increase the particles' specific binding to the desired targets. This article reviews the current research on NIR light-activatable AuNSs used as nanocarriers for drug delivery systems and cancer theranostics.
KW - drug delivery
KW - gold nanoshells
KW - nanocarrier
KW - theranostics
KW - triggered release
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U2 - 10.1208/s12249-014-0097-8
DO - 10.1208/s12249-014-0097-8
M3 - Review article
C2 - 24550102
AN - SCOPUS:84901985112
SN - 1530-9932
VL - 15
SP - 741
EP - 752
JO - AAPS PharmSciTech
JF - AAPS PharmSciTech
IS - 3
ER -