TY - JOUR
T1 - Light‐heavy chain deposition disease progressing to multiple myeloma
AU - Daliani, Danai
AU - Weber, Donna
AU - Alexanian, Raymond
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1995/12
Y1 - 1995/12
N2 - Light chain deposition disease (LCDD) and light and heavy chain deposition disease (LHCDD) are rare clinical entities that have been associated with multiple myeloma, with monoclonal gammopathy of unknown significance (MGUS), or without any detectable protein abnormality. Renal failure is common, the diagnosis is difficult and prolonged survival is rare. The first patient with LHCDD and MGUS who progressed to multiple myeloma after 11 years is presented. A rising level of monoclonal IgA immunoglobulin, bone marrow plasmacytosis, and the presence of multiple bone marrow lesions on magnetic resonance imaging provided the first evidence of disease evolution. When management of serious complications permits a long survival, some patients with LCDD or LHCDD will develop multiple myeloma.
AB - Light chain deposition disease (LCDD) and light and heavy chain deposition disease (LHCDD) are rare clinical entities that have been associated with multiple myeloma, with monoclonal gammopathy of unknown significance (MGUS), or without any detectable protein abnormality. Renal failure is common, the diagnosis is difficult and prolonged survival is rare. The first patient with LHCDD and MGUS who progressed to multiple myeloma after 11 years is presented. A rising level of monoclonal IgA immunoglobulin, bone marrow plasmacytosis, and the presence of multiple bone marrow lesions on magnetic resonance imaging provided the first evidence of disease evolution. When management of serious complications permits a long survival, some patients with LCDD or LHCDD will develop multiple myeloma.
KW - light‐heavy chain deposition disease
KW - magnetic resonance imaging
KW - multiple myeloma
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U2 - 10.1002/ajh.2830500413
DO - 10.1002/ajh.2830500413
M3 - Article
C2 - 7485106
AN - SCOPUS:0029621914
SN - 0361-8609
VL - 50
SP - 296
EP - 298
JO - American journal of hematology
JF - American journal of hematology
IS - 4
ER -