Lipid metabolism in tumor immunology and immunotherapy

Lisa K. Duong; Halil Ibrahim Corbali; Thomas S. Riad; Shonik Ganjoo; Selene Nanez; Tiffany Voss; Hampartsum Barsomium; James Welsh; Maria Angelica Cortez

doi:10.3389/fonc.2023.1187279

Lipid metabolism in tumor immunology and immunotherapy

Lisa K. Duong, Halil Ibrahim Corbali, Thomas S. Riad, Shonik Ganjoo, Selene Nanez, Tiffany Voss, Hampartsum Barsomium, James Welsh, Maria Angelica Cortez

Research output: Contribution to journal › Review article › peer-review

Abstract

Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their importance in cellular functions and their potential as cancer biomarkers have been explored, lipids have yet to be extensively investigated as a possible form of cancer therapy. This review explores the role of lipids in cancer pathophysiology and describes how further understanding of these macromolecules could prompt novel treatments for cancer.

Original language	English (US)
Article number	1187279
Journal	Frontiers in Oncology
Volume	13
DOIs	https://doi.org/10.3389/fonc.2023.1187279
State	Published - 2023

Keywords

cancer
immune cells
immunotherapy
lipid oxidation
lipids

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2023.1187279

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title = "Lipid metabolism in tumor immunology and immunotherapy",

abstract = "Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their importance in cellular functions and their potential as cancer biomarkers have been explored, lipids have yet to be extensively investigated as a possible form of cancer therapy. This review explores the role of lipids in cancer pathophysiology and describes how further understanding of these macromolecules could prompt novel treatments for cancer.",

keywords = "cancer, immune cells, immunotherapy, lipid oxidation, lipids",

author = "Duong, {Lisa K.} and Corbali, {Halil Ibrahim} and Riad, {Thomas S.} and Shonik Ganjoo and Selene Nanez and Tiffany Voss and Hampartsum Barsomium and James Welsh and Cortez, {Maria Angelica}",

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year = "2023",

doi = "10.3389/fonc.2023.1187279",

language = "English (US)",

volume = "13",

journal = "Frontiers in Oncology",

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T1 - Lipid metabolism in tumor immunology and immunotherapy

AU - Duong, Lisa K.

AU - Corbali, Halil Ibrahim

AU - Riad, Thomas S.

AU - Ganjoo, Shonik

AU - Nanez, Selene

AU - Voss, Tiffany

AU - Barsomium, Hampartsum

AU - Welsh, James

AU - Cortez, Maria Angelica

PY - 2023

Y1 - 2023

N2 - Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their importance in cellular functions and their potential as cancer biomarkers have been explored, lipids have yet to be extensively investigated as a possible form of cancer therapy. This review explores the role of lipids in cancer pathophysiology and describes how further understanding of these macromolecules could prompt novel treatments for cancer.

AB - Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their importance in cellular functions and their potential as cancer biomarkers have been explored, lipids have yet to be extensively investigated as a possible form of cancer therapy. This review explores the role of lipids in cancer pathophysiology and describes how further understanding of these macromolecules could prompt novel treatments for cancer.

KW - cancer

KW - immune cells

KW - immunotherapy

KW - lipid oxidation

KW - lipids

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DO - 10.3389/fonc.2023.1187279

M3 - Review article

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AN - SCOPUS:85159894705

SN - 2234-943X

VL - 13

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 1187279

ER -

Lipid metabolism in tumor immunology and immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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