TY - JOUR
T1 - Lipopolysaccharide activates toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes
AU - Guijarro-Muñoz, Irene
AU - Compte, Marta
AU - Álvarez-Cienfuegos, Ana
AU - Álvarez-Vallina, Luis
AU - Sanz, Laura
PY - 2014/1/24
Y1 - 2014/1/24
N2 - Background: Endothelial cells are well known inflammatory effectors, but TLR4 expression and function in human pericytes have not been addressed. Results: Pericytes express TLR4, and stimulation with LPS or HMGB1 promotes cytokine and chemokine secretion and overexpression of adhesion molecules via NF-κB. Conclusion: TLR4 activation in pericytes triggers a proinflammatory and proangiogenic program. Significance: Pericytes are active players in inflammatory responses beyond their homeostatic role.
AB - Background: Endothelial cells are well known inflammatory effectors, but TLR4 expression and function in human pericytes have not been addressed. Results: Pericytes express TLR4, and stimulation with LPS or HMGB1 promotes cytokine and chemokine secretion and overexpression of adhesion molecules via NF-κB. Conclusion: TLR4 activation in pericytes triggers a proinflammatory and proangiogenic program. Significance: Pericytes are active players in inflammatory responses beyond their homeostatic role.
UR - http://www.scopus.com/inward/record.url?scp=84893073902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893073902&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.521161
DO - 10.1074/jbc.M113.521161
M3 - Article
C2 - 24307174
AN - SCOPUS:84893073902
SN - 0021-9258
VL - 289
SP - 2457
EP - 2468
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 4
ER -