Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin

Shuai Wu; Shui Di Zheng; Hong Ling Huang; Li Chong Yan; Xiao Fei Yin; Hai Neng Xu; Kang Jian Zhang; Jing Hua Gui; Liang Chu; Xin Yuan Liu

doi:10.1074/jbc.M113.479865

Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin

Shuai Wu, Shui Di Zheng, Hong Ling Huang, Li Chong Yan, Xiao Fei Yin, Hai Neng Xu, Kang Jian Zhang, Jing Hua Gui, Liang Chu, Xin Yuan Liu

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Background: Lithium and valproic acid (VPA) exhibit a robust neuroprotective and anti-tumor effects in neural cells and tumor cells. Results: Lithium significantly down-regulates HDAC1 at the translational level by targeting HDAC1 mRNA. Conclusion: The decrease in HDAC1 is essential for the lithium-mediated, autophagic degradation of mutant huntingtin. Significance: This report is the first demonstration that HDAC1 decreases in response to lithium treatment.

Original language	English (US)
Pages (from-to)	35604-35616
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	49
DOIs	https://doi.org/10.1074/jbc.M113.479865
State	Published - Dec 6 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.479865

Cite this

@article{2a3e21b0addf413881c99adcdec28694,

title = "Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin",

abstract = "Background: Lithium and valproic acid (VPA) exhibit a robust neuroprotective and anti-tumor effects in neural cells and tumor cells. Results: Lithium significantly down-regulates HDAC1 at the translational level by targeting HDAC1 mRNA. Conclusion: The decrease in HDAC1 is essential for the lithium-mediated, autophagic degradation of mutant huntingtin. Significance: This report is the first demonstration that HDAC1 decreases in response to lithium treatment.",

author = "Shuai Wu and Zheng, {Shui Di} and Huang, {Hong Ling} and Yan, {Li Chong} and Yin, {Xiao Fei} and Xu, {Hai Neng} and Zhang, {Kang Jian} and Gui, {Jing Hua} and Liang Chu and Liu, {Xin Yuan}",

year = "2013",

month = dec,

day = "6",

doi = "10.1074/jbc.M113.479865",

language = "English (US)",

volume = "288",

pages = "35604--35616",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "49",

}

TY - JOUR

T1 - Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin

AU - Wu, Shuai

AU - Zheng, Shui Di

AU - Huang, Hong Ling

AU - Yan, Li Chong

AU - Yin, Xiao Fei

AU - Xu, Hai Neng

AU - Zhang, Kang Jian

AU - Gui, Jing Hua

AU - Chu, Liang

AU - Liu, Xin Yuan

PY - 2013/12/6

Y1 - 2013/12/6

N2 - Background: Lithium and valproic acid (VPA) exhibit a robust neuroprotective and anti-tumor effects in neural cells and tumor cells. Results: Lithium significantly down-regulates HDAC1 at the translational level by targeting HDAC1 mRNA. Conclusion: The decrease in HDAC1 is essential for the lithium-mediated, autophagic degradation of mutant huntingtin. Significance: This report is the first demonstration that HDAC1 decreases in response to lithium treatment.

AB - Background: Lithium and valproic acid (VPA) exhibit a robust neuroprotective and anti-tumor effects in neural cells and tumor cells. Results: Lithium significantly down-regulates HDAC1 at the translational level by targeting HDAC1 mRNA. Conclusion: The decrease in HDAC1 is essential for the lithium-mediated, autophagic degradation of mutant huntingtin. Significance: This report is the first demonstration that HDAC1 decreases in response to lithium treatment.

UR - http://www.scopus.com/inward/record.url?scp=84894355071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894355071&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.479865

DO - 10.1074/jbc.M113.479865

M3 - Article

C2 - 24165128

AN - SCOPUS:84894355071

SN - 0021-9258

VL - 288

SP - 35604

EP - 35616

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 49

ER -

Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this