TY - JOUR
T1 - Liver Fibrosis, Fat, and Iron Evaluation with MRI and Fibrosis and Fat Evaluation with US
T2 - A Practical Guide for Radiologists
AU - Guglielmo, Flavius F.
AU - Barr, Richard G.
AU - Yokoo, Takeshi
AU - Ferraioli, Giovanna
AU - Lee, James T.
AU - Dillman, Jonathan R.
AU - Horowitz, Jeanne M.
AU - Jhaveri, Kartik S.
AU - Miller, Frank H.
AU - Modi, Roshan Y.
AU - Mojtahed, Amirkasra
AU - Ohliger, Michael A.
AU - Pirasteh, Ali
AU - Reeder, Scott B.
AU - Shanbhogue, Krishna
AU - Silva, Alvin C.
AU - Smith, Elainea N.
AU - Surabhi, Venkateswar R.
AU - Taouli, Bachir
AU - Welle, Christopher L.
AU - Yeh, Benjamin M.
AU - Venkatesh, Sudhakar K.
N1 - Publisher Copyright:
© RSNA, 2023.
PY - 2023/6
Y1 - 2023/6
N2 - Quantitative imaging biomarkers of liver disease measured by using MRI and US are emerging as important clinical tools in the management of patients with chronic liver disease (CLD). Because of their high accuracy and noninvasive nature, in many cases, these techniques have replaced liver biopsy for the diagnosis, quantitative staging, and treatment monitoring of patients with CLD. The most commonly evaluated imaging biomarkers are surrogates for liver fibrosis, fat, and iron. MR elastography is now routinely performed to evaluate for liver fibrosis and typically combined with MRI-based liver fat and iron quantification to exclude or grade hepatic steatosis and iron overload, respectively. US elastography is also widely performed to evaluate for liver fibrosis and has the advantage of lower equipment cost and greater availability compared with those of MRI. Emerging US fat quantification methods can be performed along with US elastography. The author group, consisting of members of the Society of Abdominal Radiology (SAR) Liver Fibrosis Disease-Focused Panel (DFP), the SAR Hepatic Iron Overload DFP, and the European Society of Radiology, review the basics of liver fibrosis, fat, and iron quantification with MRI and liver fibrosis and fat quantification with US. The authors cover technical requirements, typical case display, quality control and proper measurement technique and case interpretation guidelines, pitfalls, and confounding factors. The authors aim to provide a practical guide for radiologists interpreting these examinations.
AB - Quantitative imaging biomarkers of liver disease measured by using MRI and US are emerging as important clinical tools in the management of patients with chronic liver disease (CLD). Because of their high accuracy and noninvasive nature, in many cases, these techniques have replaced liver biopsy for the diagnosis, quantitative staging, and treatment monitoring of patients with CLD. The most commonly evaluated imaging biomarkers are surrogates for liver fibrosis, fat, and iron. MR elastography is now routinely performed to evaluate for liver fibrosis and typically combined with MRI-based liver fat and iron quantification to exclude or grade hepatic steatosis and iron overload, respectively. US elastography is also widely performed to evaluate for liver fibrosis and has the advantage of lower equipment cost and greater availability compared with those of MRI. Emerging US fat quantification methods can be performed along with US elastography. The author group, consisting of members of the Society of Abdominal Radiology (SAR) Liver Fibrosis Disease-Focused Panel (DFP), the SAR Hepatic Iron Overload DFP, and the European Society of Radiology, review the basics of liver fibrosis, fat, and iron quantification with MRI and liver fibrosis and fat quantification with US. The authors cover technical requirements, typical case display, quality control and proper measurement technique and case interpretation guidelines, pitfalls, and confounding factors. The authors aim to provide a practical guide for radiologists interpreting these examinations.
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U2 - 10.1148/rg.220181
DO - 10.1148/rg.220181
M3 - Article
C2 - 37227944
AN - SCOPUS:85160458646
SN - 0271-5333
VL - 43
JO - Radiographics
JF - Radiographics
IS - 6
M1 - e220181
ER -