Lmx1b is essential for the development of serotonergic neurons

Yu Qiang Ding; Ulrika Marklund; Wenlin Yuan; Jun Yin; Lauren Wegman; Johan Ericson; Evan Deneris; Randy L. Johnson; Zhou Feng Chen

doi:10.1038/nn1104

Lmx1b is essential for the development of serotonergic neurons

Yu Qiang Ding, Ulrika Marklund, Wenlin Yuan, Jun Yin, Lauren Wegman, Johan Ericson, Evan Deneris, Randy L. Johnson, Zhou Feng Chen

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227 Scopus citations

Abstract

The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice. A major determinant in the cascades is an LIM homeodomain-containing gene, Lmx1b, which is required for the development of all 5-HT neurons in the central nervous system. Our results suggest that, during development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples Nkx2-2-mediated early specification with Pet1-mediated terminal differentiation. Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components.

Original language	English (US)
Pages (from-to)	933-938
Number of pages	6
Journal	Nature Neuroscience
Volume	6
Issue number	9
DOIs	https://doi.org/10.1038/nn1104
State	Published - Sep 1 2003

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn1104

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title = "Lmx1b is essential for the development of serotonergic neurons",

abstract = "The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice. A major determinant in the cascades is an LIM homeodomain-containing gene, Lmx1b, which is required for the development of all 5-HT neurons in the central nervous system. Our results suggest that, during development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples Nkx2-2-mediated early specification with Pet1-mediated terminal differentiation. Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components.",

author = "Ding, {Yu Qiang} and Ulrika Marklund and Wenlin Yuan and Jun Yin and Lauren Wegman and Johan Ericson and Evan Deneris and Johnson, {Randy L.} and Chen, {Zhou Feng}",

note = "Funding Information: We thank T. Jessell, J. Brunet, W. Wurst and M. Minami for reagents. We thank E.M. Johnson Jr. and M.F. Jacquin for comments on the manuscript. The project was supported by a NIH grant to Z-F.C. J.E. was supported by the Royal Swedish Academy of Sciences by a donation from the Wallenberg Foundation, The Swedish Foundation for Strategic Research, The Swedish National Research council, Brainstem Genetics: QLRT-2000-01467 and Stembridge: OLG3-CT-2002-01141. E.D. was supported by a NIH grant.",

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AU - Ding, Yu Qiang

AU - Marklund, Ulrika

AU - Yuan, Wenlin

AU - Yin, Jun

AU - Wegman, Lauren

AU - Ericson, Johan

AU - Deneris, Evan

AU - Johnson, Randy L.

AU - Chen, Zhou Feng

N1 - Funding Information: We thank T. Jessell, J. Brunet, W. Wurst and M. Minami for reagents. We thank E.M. Johnson Jr. and M.F. Jacquin for comments on the manuscript. The project was supported by a NIH grant to Z-F.C. J.E. was supported by the Royal Swedish Academy of Sciences by a donation from the Wallenberg Foundation, The Swedish Foundation for Strategic Research, The Swedish National Research council, Brainstem Genetics: QLRT-2000-01467 and Stembridge: OLG3-CT-2002-01141. E.D. was supported by a NIH grant.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice. A major determinant in the cascades is an LIM homeodomain-containing gene, Lmx1b, which is required for the development of all 5-HT neurons in the central nervous system. Our results suggest that, during development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples Nkx2-2-mediated early specification with Pet1-mediated terminal differentiation. Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components.

AB - The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice. A major determinant in the cascades is an LIM homeodomain-containing gene, Lmx1b, which is required for the development of all 5-HT neurons in the central nervous system. Our results suggest that, during development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples Nkx2-2-mediated early specification with Pet1-mediated terminal differentiation. Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components.

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Lmx1b is essential for the development of serotonergic neurons

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