Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis

Usha R. Reddy; Sagar Phatak; Cindy Allen; Lynn M. Nycum; Erik P. Sulman; Peter S. White; Jaclyn A. Biegel

doi:10.1006/geno.1997.4653

Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis

Usha R. Reddy, Sagar Phatak, Cindy Allen, Lynn M. Nycum, Erik P. Sulman, Peter S. White, Jaclyn A. Biegel

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene.

Original language	English (US)
Pages (from-to)	283-285
Number of pages	3
Journal	Genomics
Volume	41
Issue number	2
DOIs	https://doi.org/10.1006/geno.1997.4653
State	Published - Apr 15 1997

ASJC Scopus subject areas

Genetics

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10.1006/geno.1997.4653

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title = "Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis",

abstract = "Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene.",

author = "Reddy, {Usha R.} and Sagar Phatak and Cindy Allen and Nycum, {Lynn M.} and Sulman, {Erik P.} and White, {Peter S.} and Biegel, {Jaclyn A.}",

note = "Funding Information: This work was supported by grants from the NIH (NS08075, NS25044), and from the Ronald McDonald Children's Charities and NIH CA 46274 to J.A.B. We gratefully acknowledge Dr. David Pleasure and Dr. Garrett Brodeur for helpful discussions.",

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doi = "10.1006/geno.1997.4653",

language = "English (US)",

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T1 - Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis

AU - Reddy, Usha R.

AU - Phatak, Sagar

AU - Allen, Cindy

AU - Nycum, Lynn M.

AU - Sulman, Erik P.

AU - White, Peter S.

AU - Biegel, Jaclyn A.

N1 - Funding Information: This work was supported by grants from the NIH (NS08075, NS25044), and from the Ronald McDonald Children's Charities and NIH CA 46274 to J.A.B. We gratefully acknowledge Dr. David Pleasure and Dr. Garrett Brodeur for helpful discussions.

PY - 1997/4/15

Y1 - 1997/4/15

N2 - Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene.

AB - Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene.

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Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis

Abstract

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