TY - JOUR
T1 - Locoregional Therapies in Immunologically “Cold” Tumors
T2 - Opportunities and Clinical Trial Design Considerations
AU - Msaouel, Pavlos
AU - Sheth, Rahul A.
N1 - Publisher Copyright:
© 2023 SIR
PY - 2024/2
Y1 - 2024/2
N2 - Immunotherapy has revolutionized cancer management, but many tumors, particularly immunologically “cold” tumors, remain resistant to the therapy. The combination of conventional systemic immunotherapies and locoregional interventional radiology approaches is being explored to transform these cold tumors into immunologically active “hot” ones. The present article uses the example of chromophobe renal cell carcinoma (ChRCC), a renal cell carcinoma subtype resistant to current systemic immunotherapies, to address practical and conceptual challenges that have prevented the activation of clinical trials specifically designed for this malignancy to date. The practical framework discussed herein can help overcome logistic and funding limitations and facilitate the development of biology-informed clinical trials tailored to specific rare diseases such as ChRCC.
AB - Immunotherapy has revolutionized cancer management, but many tumors, particularly immunologically “cold” tumors, remain resistant to the therapy. The combination of conventional systemic immunotherapies and locoregional interventional radiology approaches is being explored to transform these cold tumors into immunologically active “hot” ones. The present article uses the example of chromophobe renal cell carcinoma (ChRCC), a renal cell carcinoma subtype resistant to current systemic immunotherapies, to address practical and conceptual challenges that have prevented the activation of clinical trials specifically designed for this malignancy to date. The practical framework discussed herein can help overcome logistic and funding limitations and facilitate the development of biology-informed clinical trials tailored to specific rare diseases such as ChRCC.
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U2 - 10.1016/j.jvir.2023.09.035
DO - 10.1016/j.jvir.2023.09.035
M3 - Review article
C2 - 38272640
AN - SCOPUS:85182580041
SN - 1051-0443
VL - 35
SP - 198
EP - 202
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 2
ER -