TY - JOUR
T1 - Long-term clinical responses of neoadjuvant dendritic cell infusions and radiation in soft tissue sarcoma
AU - Raj, Shailaja
AU - Bui, Marilyn M.
AU - Springett, Gregory
AU - Conley, Anthony
AU - Lavilla-Alonso, Sergio
AU - Zhao, Xiuhua
AU - Chen, Dungsa
AU - Haysek, Randy
AU - Gonzalez, Ricardo
AU - Letson, G. Douglas
AU - Finkelstein, Steven Eric
AU - Chiappori, Alberto A.
AU - Gabrilovitch, Dmitry I.
AU - Antonia, Scott J.
N1 - Publisher Copyright:
© 2015 Shailaja Raj et al.
PY - 2015
Y1 - 2015
N2 - Purpose. Patients with large >5 cm, high-grade resectable soft tissue sarcomas (STS) have the highest risk of distant metastases. Previously we have shown that dendritic cell (DC) based vaccines show consistent immune responses. Methods. This was a Phase I single institution study of neoadjuvant radiation with DC injections on 18 newly diagnosed high-risk STS patients. Neoadjuvant treatment consisted of 50 Gy of external beam radiation (EBRT), given in 25 fractions delivered five days/week, combined with four intratumoral injections of DCs followed by complete resection. The primary endpoint was to establish the immunological response to neoadjuvant therapy and obtain data on its clinical safety and outcomes. Results. There were no unexpected toxicities or serious adverse events. Twelve out of 18 (67%) patients were alive, of which an encouraging 11/18 (61%) were alive with no systemic recurrence over a period of 2-8 years. Favorable immunological responses correlated with clinical responses in some cases. Conclusions. This study provides clinical support to using dendritic cell injections along with radiation in sarcomas, which when used optimally in combination can help clinical outcomes in soft tissue sarcoma. Study registration number is NCT00365872.
AB - Purpose. Patients with large >5 cm, high-grade resectable soft tissue sarcomas (STS) have the highest risk of distant metastases. Previously we have shown that dendritic cell (DC) based vaccines show consistent immune responses. Methods. This was a Phase I single institution study of neoadjuvant radiation with DC injections on 18 newly diagnosed high-risk STS patients. Neoadjuvant treatment consisted of 50 Gy of external beam radiation (EBRT), given in 25 fractions delivered five days/week, combined with four intratumoral injections of DCs followed by complete resection. The primary endpoint was to establish the immunological response to neoadjuvant therapy and obtain data on its clinical safety and outcomes. Results. There were no unexpected toxicities or serious adverse events. Twelve out of 18 (67%) patients were alive, of which an encouraging 11/18 (61%) were alive with no systemic recurrence over a period of 2-8 years. Favorable immunological responses correlated with clinical responses in some cases. Conclusions. This study provides clinical support to using dendritic cell injections along with radiation in sarcomas, which when used optimally in combination can help clinical outcomes in soft tissue sarcoma. Study registration number is NCT00365872.
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U2 - 10.1155/2015/614736
DO - 10.1155/2015/614736
M3 - Article
C2 - 26880867
AN - SCOPUS:84956875433
SN - 1357-714X
VL - 2015
JO - Sarcoma
JF - Sarcoma
M1 - 614736
ER -