Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer

Jack A. Roth; E. Neely Atkinson; Frank Fossella; Ritsuko Komaki; M. Bernadette Ryan; J. B. Putnam; Jin Soo Lee; Hari Dhingra; Louis De Caro; Marvin Chasen; Waun Ki Hong

doi:10.1016/S0169-5002(98)00046-4

Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer

Jack A. Roth, E. Neely Atkinson, Frank Fossella, Ritsuko Komaki, M. Bernadette Ryan, J. B. Putnam, Jin Soo Lee, Hari Dhingra, Louis De Caro, Marvin Chasen, Waun Ki Hong

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Abstract

Our previously reported randomized study of patients with untreated, potentially resectable clinical stage IIIA non-small-cell lung cancer found that patients treated with perioperative chemotherapy and surgery had a significant increase in median survival compared to patients treated with surgery alone. We have now re-analyzed the results of the study with a median time from random allocation to analysis for all patients of 82 months. The increase in survival conferred by perioperative chemotherapy was maintained during the period of extended observation. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Lung Cancer
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/S0169-5002(98)00046-4
State	Published - Jul 1998

Keywords

Cisplatin
Induction chemotherapy
Lung cancer
Randomized trial

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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Roth, J. A., Atkinson, E. N., Fossella, F., Komaki, R., Ryan, M. B., Putnam, J. B., Lee, J. S., Dhingra, H., De Caro, L., Chasen, M., & Hong, W. K. (1998). Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. Lung Cancer, 21(1), 1-6. https://doi.org/10.1016/S0169-5002(98)00046-4

Roth, JA, Atkinson, EN, Fossella, F, Komaki, R, Ryan, MB, Putnam, JB, Lee, JS, Dhingra, H, De Caro, L, Chasen, M & Hong, WK 1998, 'Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer', Lung Cancer, vol. 21, no. 1, pp. 1-6. https://doi.org/10.1016/S0169-5002(98)00046-4

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title = "Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer",

abstract = "Our previously reported randomized study of patients with untreated, potentially resectable clinical stage IIIA non-small-cell lung cancer found that patients treated with perioperative chemotherapy and surgery had a significant increase in median survival compared to patients treated with surgery alone. We have now re-analyzed the results of the study with a median time from random allocation to analysis for all patients of 82 months. The increase in survival conferred by perioperative chemotherapy was maintained during the period of extended observation. Copyright (C) 1998 Elsevier Science Ireland Ltd.",

keywords = "Cisplatin, Induction chemotherapy, Lung cancer, Randomized trial",

author = "Roth, {Jack A.} and Atkinson, {E. Neely} and Frank Fossella and Ritsuko Komaki and Ryan, {M. Bernadette} and Putnam, {J. B.} and Lee, {Jin Soo} and Hari Dhingra and {De Caro}, Louis and Marvin Chasen and Hong, {Waun Ki}",

note = "Funding Information: We wish to thank Monica Contreras for preparation of the manuscript. This study was partially supported by the Specialized Program of Research Excellence (SPORE) in Lung Cancer (P50-CA70907) and by the UT M.D. Anderson Cancer Center Support Core Grant (CA16672). ",

year = "1998",

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doi = "10.1016/S0169-5002(98)00046-4",

language = "English (US)",

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AU - Atkinson, E. Neely

AU - Fossella, Frank

AU - Komaki, Ritsuko

AU - Ryan, M. Bernadette

AU - Putnam, J. B.

AU - Lee, Jin Soo

AU - Dhingra, Hari

AU - De Caro, Louis

AU - Chasen, Marvin

AU - Hong, Waun Ki

N1 - Funding Information: We wish to thank Monica Contreras for preparation of the manuscript. This study was partially supported by the Specialized Program of Research Excellence (SPORE) in Lung Cancer (P50-CA70907) and by the UT M.D. Anderson Cancer Center Support Core Grant (CA16672).

PY - 1998/7

Y1 - 1998/7

N2 - Our previously reported randomized study of patients with untreated, potentially resectable clinical stage IIIA non-small-cell lung cancer found that patients treated with perioperative chemotherapy and surgery had a significant increase in median survival compared to patients treated with surgery alone. We have now re-analyzed the results of the study with a median time from random allocation to analysis for all patients of 82 months. The increase in survival conferred by perioperative chemotherapy was maintained during the period of extended observation. Copyright (C) 1998 Elsevier Science Ireland Ltd.

AB - Our previously reported randomized study of patients with untreated, potentially resectable clinical stage IIIA non-small-cell lung cancer found that patients treated with perioperative chemotherapy and surgery had a significant increase in median survival compared to patients treated with surgery alone. We have now re-analyzed the results of the study with a median time from random allocation to analysis for all patients of 82 months. The increase in survival conferred by perioperative chemotherapy was maintained during the period of extended observation. Copyright (C) 1998 Elsevier Science Ireland Ltd.

KW - Cisplatin

KW - Induction chemotherapy

KW - Lung cancer

KW - Randomized trial

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Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer

Abstract

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