Abstract
Dasatinib is a potent oral tyrosine kinase inhibitor which targets several kinases, including the SRC family kinases. SRC family kinases have been implicated in androgen therapy resistance that often develops in metastatic castration-resistant prostate cancer (mCRPC), which drives the need for non-androgen targeting therapies. This article describes the preclinical rationale for the use of combination dasatinib and docetaxel therapy in mCRPC, and highlights the results of a phase I-II trial in which 46 patients with mCRPC, treated with a regimen of dasatinib and docetaxel, demonstrated improvements in bone scans, high rates of soft tissue responses, and modulation of markers of bone turnover. This brief report discusses in detail follow-up data on two patients who remain alive after >2.5 years on dasatinib single-agent therapy after discontinuing docetaxel treatment.
Original language | English (US) |
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Pages (from-to) | 25-30 |
Number of pages | 6 |
Journal | Cancer Management and Research |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Mar 8 2013 |
Keywords
- Case study
- Dasatinib
- Docetaxel
- Prostate cancer
- Targeted therapy
ASJC Scopus subject areas
- Oncology