Abstract
Seizure is a recognized complication of high-dose busulfan (BU) therapy and phenytoin (DPH) is widely used as prophylaxis. A number of adverse effects have been associated with DPH and it may also interfere with BU metabolism. We used lorazepam (median dose 0.022 mg/kg) i.v. or p.o. before each dose and for 24 h after the last dose of BU as seizure prophylaxis to 29 children undergoing hematopoietic stem cell transplantation. The regimen was well tolerated and drowsiness was the only significant side-effect. Twelve patients were able to receive the entire prophylaxis by mouth. No seizure developed during and within 48 h of BU. Concomitant pharmacokinetic studies showed no alternation of the absorption and clearance of BU during lorazepam administration. Lorazepam can be used as an alternative for seizure prophylaxis during high-dose BU treatment.
Original language | English (US) |
---|---|
Pages (from-to) | 963-965 |
Number of pages | 3 |
Journal | Bone marrow transplantation |
Volume | 29 |
Issue number | 12 |
DOIs | |
State | Published - 2002 |
Keywords
- Hematopoietic stem cell transplantation
- High-dose busulfan
- Lorazepam
- Pediatrics
- Phenytoin
- Seizure
ASJC Scopus subject areas
- Hematology
- Transplantation