Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: Role on the transcriptional and proangiogenic profiles of CD138+ cells

S. Colla; P. Storti; G. Donofrio; K. Todoerti; M. Bolzoni; M. Lazzaretti; M. Abeltino; L. Ippolito; A. Neri; D. Ribatti; V. Rizzoli; E. Martella; N. Giuliani

doi:10.1038/leu.2010.193

Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: Role on the transcriptional and proangiogenic profiles of CD138⁺ cells

S. Colla, P. Storti, G. Donofrio, K. Todoerti, M. Bolzoni, M. Lazzaretti, M. Abeltino, L. Ippolito, A. Neri, D. Ribatti, V. Rizzoli, E. Martella, N. Giuliani

Research output: Contribution to journal › Letter › peer-review

100 Scopus citations

Original language	English (US)
Pages (from-to)	1967-1970
Number of pages	4
Journal	Leukemia
Volume	24
Issue number	11
DOIs	https://doi.org/10.1038/leu.2010.193
State	Published - Nov 23 2010
Externally published	Yes

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/leu.2010.193

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Colla, S., Storti, P., Donofrio, G., Todoerti, K., Bolzoni, M., Lazzaretti, M., Abeltino, M., Ippolito, L., Neri, A., Ribatti, D., Rizzoli, V., Martella, E., & Giuliani, N. (2010). Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: Role on the transcriptional and proangiogenic profiles of CD138⁺ cells. Leukemia, 24(11), 1967-1970. https://doi.org/10.1038/leu.2010.193

Colla, S, Storti, P, Donofrio, G, Todoerti, K, Bolzoni, M, Lazzaretti, M, Abeltino, M, Ippolito, L, Neri, A, Ribatti, D, Rizzoli, V, Martella, E & Giuliani, N 2010, 'Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: Role on the transcriptional and proangiogenic profiles of CD138⁺ cells', Leukemia, vol. 24, no. 11, pp. 1967-1970. https://doi.org/10.1038/leu.2010.193

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title = "Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: Role on the transcriptional and proangiogenic profiles of CD138+ cells",

author = "S. Colla and P. Storti and G. Donofrio and K. Todoerti and M. Bolzoni and M. Lazzaretti and M. Abeltino and L. Ippolito and A. Neri and D. Ribatti and V. Rizzoli and E. Martella and N. Giuliani",

note = "Funding Information: The technical assistance of B{\"a}rbel L{\"o}bel, Karin G{\"u}nther, Jule Kriegel and Anne Seltmann (all from the Institute of Immunology) is greatly appreciated. We also thank Silke Soucek and Michael Kramer for providing the characteristics of the AML cells. This work was supported by grants from the Deutsche Forschungsge-meinschaft to MB and GE (SFB655, project B2 and B7) and from the Medical Faculty, Technical University of Dresden to RW. Funding Information: We thank the {\textquoteleft}Associazione Italiana Contro le Leucemie{\textquoteright} (AIL) Parma section and the Associazione Italiana Ricerca sul Cancro (AIRC) for the financial support (IG2009). This study was supported by grants from the {\textquoteleft}International Myeloma Foundation{\textquoteright}; the {\textquoteleft}Italian Minister of Health-Progetti Regione Emilia Romagna{\textquoteright}.",

year = "2010",

month = nov,

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doi = "10.1038/leu.2010.193",

language = "English (US)",

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T1 - Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma

T2 - Role on the transcriptional and proangiogenic profiles of CD138+ cells

AU - Colla, S.

AU - Storti, P.

AU - Donofrio, G.

AU - Todoerti, K.

AU - Bolzoni, M.

AU - Lazzaretti, M.

AU - Abeltino, M.

AU - Ippolito, L.

AU - Neri, A.

AU - Ribatti, D.

AU - Rizzoli, V.

AU - Martella, E.

AU - Giuliani, N.

N1 - Funding Information: The technical assistance of Bärbel Löbel, Karin Günther, Jule Kriegel and Anne Seltmann (all from the Institute of Immunology) is greatly appreciated. We also thank Silke Soucek and Michael Kramer for providing the characteristics of the AML cells. This work was supported by grants from the Deutsche Forschungsge-meinschaft to MB and GE (SFB655, project B2 and B7) and from the Medical Faculty, Technical University of Dresden to RW. Funding Information: We thank the ‘Associazione Italiana Contro le Leucemie’ (AIL) Parma section and the Associazione Italiana Ricerca sul Cancro (AIRC) for the financial support (IG2009). This study was supported by grants from the ‘International Myeloma Foundation’; the ‘Italian Minister of Health-Progetti Regione Emilia Romagna’.

PY - 2010/11/23

Y1 - 2010/11/23

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DO - 10.1038/leu.2010.193

M3 - Letter

C2 - 20811474

AN - SCOPUS:78149468597

SN - 0887-6924

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SP - 1967

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JO - Leukemia

JF - Leukemia

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Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: Role on the transcriptional and proangiogenic profiles of CD138+ cells

ASJC Scopus subject areas

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Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: Role on the transcriptional and proangiogenic profiles of CD138⁺ cells