Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

Julien Berthiller; Kurt Straif; Antonio Agudo; Wolfgang Ahrens; Alexandre Bezerra Dos Santos; Stefania Boccia; Gabriella Cadoni; Cristina Canova; Xavier Castellsague; Chu Chen; David Conway; Maria Paula Curado; Luigino Dal Maso; Alexander W. Daudt; Eleonora Fabianova; Leticia Fernandez; Silvia Franceschi; Erica E. Fukuyama; Richard B. Hayes; Claire Healy; Rolando Herrero; Ivana Holcatova; Karl Kelsey; Kristina Kjaerheim; Sergio Koifman; Pagona Lagiou; Carlo La Vecchia; Philip Lazarus; Fabio Levi; Jolanta Lissowska; Tatiana Macfarlane; Dana Mates; Michael McClean; Ana Menezes; Franco Merletti; Hal Morgenstern; Joshua Muscat; Andrew F. Olshan; Mark Purdue; Heribert Ramroth; Peter Rudnai; Stephen M. Schwartz; Diego Serraino; Oxana Shangina; Elaine Smith; Erich M. Sturgis; Neonila Szeszenia-Dabrowska; Peter Thomson; Thomas L. Vaughan; Marta Vilensky; Qingyi Wei; Deborah M. Winn; Victor Wünsch-Filho; Zuo Feng Zhang; Ariana Znaor; Gilles Ferro; Paul Brennan; Paolo Boffetta; Mia Hashibe; Yuan Chin Amy Lee

doi:10.1093/ije/dyv146

Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

Julien Berthiller, Kurt Straif, Antonio Agudo, Wolfgang Ahrens, Alexandre Bezerra Dos Santos, Stefania Boccia, Gabriella Cadoni, Cristina Canova, Xavier Castellsague, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Erica E. Fukuyama, Richard B. Hayes, Claire HealyRolando Herrero, Ivana Holcatova, Karl Kelsey, Kristina Kjaerheim, Sergio Koifman, Pagona Lagiou, Carlo La Vecchia, Philip Lazarus, Fabio Levi, Jolanta Lissowska, Tatiana Macfarlane, Dana Mates, Michael McClean, Ana Menezes, Franco Merletti, Hal Morgenstern, Joshua Muscat, Andrew F. Olshan, Mark Purdue, Heribert Ramroth, Peter Rudnai, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Neonila Szeszenia-Dabrowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Qingyi Wei, Deborah M. Winn, Victor Wünsch-Filho, Zuo Feng Zhang, Ariana Znaor, Gilles Ferro, Paul Brennan, Paolo Boffetta, Mia Hashibe, Yuan Chin Amy Lee

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Background: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers. Methods: We conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0–3, >3–5, >5–10 cigarettes per day. Results: Smoking >0–3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) ¼ 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3–5 cigarettes per day was associated in each subgroup from OR ¼ 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR ¼ 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR ¼ 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years. Conclusion: Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.

Original language	English (US)
Pages (from-to)	835-845
Number of pages	11
Journal	International journal of epidemiology
Volume	45
Issue number	3
DOIs	https://doi.org/10.1093/ije/dyv146
State	Published - Jun 2016

Keywords

Head
Low frequency cigarette smoking
Neck cancer
Pooled analysis
Risk factors

ASJC Scopus subject areas

Epidemiology

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10.1093/ije/dyv146

Cite this

Berthiller, J., Straif, K., Agudo, A., Ahrens, W., Dos Santos, A. B., Boccia, S., Cadoni, G., Canova, C., Castellsague, X., Chen, C., Conway, D., Curado, M. P., Maso, L. D., Daudt, A. W., Fabianova, E., Fernandez, L., Franceschi, S., Fukuyama, E. E., Hayes, R. B., ... Lee, Y. C. A. (2016). Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis. International journal of epidemiology, 45(3), 835-845. https://doi.org/10.1093/ije/dyv146

Berthiller, J, Straif, K, Agudo, A, Ahrens, W, Dos Santos, AB, Boccia, S, Cadoni, G, Canova, C, Castellsague, X, Chen, C, Conway, D, Curado, MP, Maso, LD, Daudt, AW, Fabianova, E, Fernandez, L, Franceschi, S, Fukuyama, EE, Hayes, RB, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, S, Lagiou, P, Vecchia, CL, Lazarus, P, Levi, F, Lissowska, J, Macfarlane, T, Mates, D, McClean, M, Menezes, A, Merletti, F, Morgenstern, H, Muscat, J, Olshan, AF, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, SM, Serraino, D, Shangina, O, Smith, E, Sturgis, EM, Szeszenia-Dabrowska, N, Thomson, P, Vaughan, TL, Vilensky, M, Wei, Q, Winn, DM, Wünsch-Filho, V, Zhang, ZF, Znaor, A, Ferro, G, Brennan, P, Boffetta, P, Hashibe, M & Lee, YCA 2016, 'Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis', International journal of epidemiology, vol. 45, no. 3, pp. 835-845. https://doi.org/10.1093/ije/dyv146

@article{fb36d81996964531b5bf27331dfd0149,

title = "Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis",

abstract = "Background: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers. Methods: We conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0–3, >3–5, >5–10 cigarettes per day. Results: Smoking >0–3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) ¼ 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3–5 cigarettes per day was associated in each subgroup from OR ¼ 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR ¼ 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR ¼ 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years. Conclusion: Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.",

keywords = "Head, Low frequency cigarette smoking, Neck cancer, Pooled analysis, Risk factors",

author = "Julien Berthiller and Kurt Straif and Antonio Agudo and Wolfgang Ahrens and {Dos Santos}, {Alexandre Bezerra} and Stefania Boccia and Gabriella Cadoni and Cristina Canova and Xavier Castellsague and Chu Chen and David Conway and Curado, {Maria Paula} and Maso, {Luigino Dal} and Daudt, {Alexander W.} and Eleonora Fabianova and Leticia Fernandez and Silvia Franceschi and Fukuyama, {Erica E.} and Hayes, {Richard B.} and Claire Healy and Rolando Herrero and Ivana Holcatova and Karl Kelsey and Kristina Kjaerheim and Sergio Koifman and Pagona Lagiou and Vecchia, {Carlo La} and Philip Lazarus and Fabio Levi and Jolanta Lissowska and Tatiana Macfarlane and Dana Mates and Michael McClean and Ana Menezes and Franco Merletti and Hal Morgenstern and Joshua Muscat and Olshan, {Andrew F.} and Mark Purdue and Heribert Ramroth and Peter Rudnai and Schwartz, {Stephen M.} and Diego Serraino and Oxana Shangina and Elaine Smith and Sturgis, {Erich M.} and Neonila Szeszenia-Dabrowska and Peter Thomson and Vaughan, {Thomas L.} and Marta Vilensky and Qingyi Wei and Winn, {Deborah M.} and Victor W{\"u}nsch-Filho and Zhang, {Zuo Feng} and Ariana Znaor and Gilles Ferro and Paul Brennan and Paolo Boffetta and Mia Hashibe and Lee, {Yuan Chin Amy}",

year = "2016",

month = jun,

doi = "10.1093/ije/dyv146",

language = "English (US)",

volume = "45",

pages = "835--845",

journal = "International journal of epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

AU - Berthiller, Julien

AU - Straif, Kurt

AU - Agudo, Antonio

AU - Ahrens, Wolfgang

AU - Dos Santos, Alexandre Bezerra

AU - Boccia, Stefania

AU - Cadoni, Gabriella

AU - Canova, Cristina

AU - Castellsague, Xavier

AU - Chen, Chu

AU - Conway, David

AU - Curado, Maria Paula

AU - Maso, Luigino Dal

AU - Daudt, Alexander W.

AU - Fabianova, Eleonora

AU - Fernandez, Leticia

AU - Franceschi, Silvia

AU - Fukuyama, Erica E.

AU - Hayes, Richard B.

AU - Healy, Claire

AU - Herrero, Rolando

AU - Holcatova, Ivana

AU - Kelsey, Karl

AU - Kjaerheim, Kristina

AU - Koifman, Sergio

AU - Lagiou, Pagona

AU - Vecchia, Carlo La

AU - Lazarus, Philip

AU - Levi, Fabio

AU - Lissowska, Jolanta

AU - Macfarlane, Tatiana

AU - Mates, Dana

AU - McClean, Michael

AU - Menezes, Ana

AU - Merletti, Franco

AU - Morgenstern, Hal

AU - Muscat, Joshua

AU - Olshan, Andrew F.

AU - Purdue, Mark

AU - Ramroth, Heribert

AU - Rudnai, Peter

AU - Schwartz, Stephen M.

AU - Serraino, Diego

AU - Shangina, Oxana

AU - Smith, Elaine

AU - Sturgis, Erich M.

AU - Szeszenia-Dabrowska, Neonila

AU - Thomson, Peter

AU - Vaughan, Thomas L.

AU - Vilensky, Marta

AU - Wei, Qingyi

AU - Winn, Deborah M.

AU - Wünsch-Filho, Victor

AU - Zhang, Zuo Feng

AU - Znaor, Ariana

AU - Ferro, Gilles

AU - Brennan, Paul

AU - Boffetta, Paolo

AU - Hashibe, Mia

AU - Lee, Yuan Chin Amy

PY - 2016/6

Y1 - 2016/6

N2 - Background: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers. Methods: We conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0–3, >3–5, >5–10 cigarettes per day. Results: Smoking >0–3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) ¼ 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3–5 cigarettes per day was associated in each subgroup from OR ¼ 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR ¼ 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR ¼ 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years. Conclusion: Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.

AB - Background: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers. Methods: We conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0–3, >3–5, >5–10 cigarettes per day. Results: Smoking >0–3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) ¼ 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3–5 cigarettes per day was associated in each subgroup from OR ¼ 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR ¼ 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR ¼ 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years. Conclusion: Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.

KW - Head

KW - Low frequency cigarette smoking

KW - Neck cancer

KW - Pooled analysis

KW - Risk factors

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U2 - 10.1093/ije/dyv146

DO - 10.1093/ije/dyv146

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AN - SCOPUS:85011276656

SN - 0300-5771

VL - 45

SP - 835

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JO - International journal of epidemiology

JF - International journal of epidemiology

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ER -

Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

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