TY - JOUR
T1 - Lower Rates of Hypocalcemia Following Near-Infrared Autofluorescence Use in Thyroidectomy
T2 - A Meta-Analysis of RCTs
AU - Rao, Karthik N.
AU - Rajguru, Renu
AU - Dange, Prajwal
AU - Vetter, Diana
AU - Triponez, Frederic
AU - Nixon, Iain J.
AU - Randolph, Gregory W.
AU - Mäkitie, Antti A.
AU - Zafereo, Mark
AU - Ferlito, Alfio
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/3
Y1 - 2024/3
N2 - Background: Iatrogenic injury of the parathyroid glands is the most frequent complication after total thyroidectomy. Objective: To determine the effectiveness of near-infrared autofluorescence (NIRAF) in reducing postoperative hypocalcemia following total thyroidectomy. Methods: PubMed, Scopus, and Google Scholar databases were searched. Randomised trials reporting at least one hypocalcemia outcome following total thyroidectomy using NIRAF were included. Results: The qualitative data synthesis comprised 1363 patients from nine randomised studies, NIRAF arm = 636 cases and non-NIRAF arm = 637 cases. There was a statistically significant difference in the overall rate of hypocalcemia log(OR) = −0.7 [(−1.01, −0.40), M-H, REM, CI = 95%] and temporary hypocalcemia log(OR) = −0.8 [(−1.01, −0.59), M-H, REM, CI = 95%] favouring the NIRAF. The difference in the rate of permanent hypocalcemia log(OR) = −1.09 [(−2.34, 0.17), M-H, REM, CI = 95%] between the two arms was lower in the NIRAF arm but was not statistically significant. Conclusions: NIRAF during total thyroidectomy helps in reducing postoperative hypocalcemia. Level of evidence—1.
AB - Background: Iatrogenic injury of the parathyroid glands is the most frequent complication after total thyroidectomy. Objective: To determine the effectiveness of near-infrared autofluorescence (NIRAF) in reducing postoperative hypocalcemia following total thyroidectomy. Methods: PubMed, Scopus, and Google Scholar databases were searched. Randomised trials reporting at least one hypocalcemia outcome following total thyroidectomy using NIRAF were included. Results: The qualitative data synthesis comprised 1363 patients from nine randomised studies, NIRAF arm = 636 cases and non-NIRAF arm = 637 cases. There was a statistically significant difference in the overall rate of hypocalcemia log(OR) = −0.7 [(−1.01, −0.40), M-H, REM, CI = 95%] and temporary hypocalcemia log(OR) = −0.8 [(−1.01, −0.59), M-H, REM, CI = 95%] favouring the NIRAF. The difference in the rate of permanent hypocalcemia log(OR) = −1.09 [(−2.34, 0.17), M-H, REM, CI = 95%] between the two arms was lower in the NIRAF arm but was not statistically significant. Conclusions: NIRAF during total thyroidectomy helps in reducing postoperative hypocalcemia. Level of evidence—1.
KW - hypocalcemia
KW - near-infrared autofluorescence
KW - outcomes
KW - thyroid gland
KW - total thyroidectomy
UR - http://www.scopus.com/inward/record.url?scp=85187470534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85187470534&partnerID=8YFLogxK
U2 - 10.3390/diagnostics14050505
DO - 10.3390/diagnostics14050505
M3 - Review article
C2 - 38472977
AN - SCOPUS:85187470534
SN - 2075-4418
VL - 14
JO - Diagnostics
JF - Diagnostics
IS - 5
M1 - 505
ER -