Lowly expressed human MicroRNA genes evolve rapidly

Han Liang; Wen Hsiung Li

doi:10.1093/molbev/msp053

Lowly expressed human MicroRNA genes evolve rapidly

Han Liang, Wen Hsiung Li

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that ∼30% of currently annotated human miRNA genes are almost free of selective pressure.

Original language	English (US)
Pages (from-to)	1195-1198
Number of pages	4
Journal	Molecular biology and evolution
Volume	26
Issue number	6
DOIs	https://doi.org/10.1093/molbev/msp053
State	Published - Jun 2009
Externally published	Yes

Keywords

MicroRNA expression
Selective pressure
Sequence divergence
Spatial clustering

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics

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10.1093/molbev/msp053

Cite this

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title = "Lowly expressed human MicroRNA genes evolve rapidly",

abstract = "To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that ∼30% of currently annotated human miRNA genes are almost free of selective pressure.",

keywords = "MicroRNA expression, Selective pressure, Sequence divergence, Spatial clustering",

author = "Han Liang and Li, {Wen Hsiung}",

year = "2009",

month = jun,

doi = "10.1093/molbev/msp053",

language = "English (US)",

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AU - Li, Wen Hsiung

PY - 2009/6

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AB - To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that ∼30% of currently annotated human miRNA genes are almost free of selective pressure.

KW - MicroRNA expression

KW - Selective pressure

KW - Sequence divergence

KW - Spatial clustering

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U2 - 10.1093/molbev/msp053

DO - 10.1093/molbev/msp053

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JO - Molecular biology and evolution

JF - Molecular biology and evolution

IS - 6

ER -

Lowly expressed human MicroRNA genes evolve rapidly

Abstract

Keywords

ASJC Scopus subject areas

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