TY - JOUR
T1 - Lung cancer after heart transplantation
T2 - A 17-year experience
AU - Potaris, Konstantinos
AU - Radovancevic, Branislav
AU - Thomas, Cynthia D.
AU - Gregoric, Igor
AU - Vaporciyan, Ara A.
AU - Riggs, Shirley A.
AU - Radovancevic, Rajko
AU - Vaughn, William K.
AU - Frazier, O. H.
PY - 2005/3
Y1 - 2005/3
N2 - Background. The effects of heart transplantation on lung cancer incidence in heart transplant recipients are unclear. Methods. In an observational study, we retrospectively reviewed the charts of all patients undergoing heart transplantation at our institution from July 1982 to July 1999. Data on lung cancer incidence, risk factors, treatment, and outcome were collected. Results. Five hundred seventy-two patients (mean age, 50 ± 11 years; range, 18 to 73) were considered at risk for lung cancer. Of these, 324 (57%) had a more than 20 pack-year history of smoking before transplantation. Lung cancer developed in 2 patients 1 year or less after transplantation and in 8 patients more than 1 year after transplantation (incidence, 2.2 per 1,000 patients per year of follow-up). Non-small cell lung cancer was diagnosed in all cases. Median survival was 10.8 months (range, 2 to 37.5). Routine annual chest radiographs after transplantation enabled early diagnosis in 5 cases (stages Ia and IIa), which correlated with better mean survival (28.1 months [range, 19 to 37.5] versus 5.1 months [range, 2 to 10.8]; p = 0.0002). Conclusions. The incidence of lung cancer in our population of heart transplant recipients appears to be no higher than in nontransplant populations with similar risk factors (ie, smoking and age). Routine radiographic imaging of transplant recipients may allow earlier detection of lung cancer and thus offer a survival benefit.
AB - Background. The effects of heart transplantation on lung cancer incidence in heart transplant recipients are unclear. Methods. In an observational study, we retrospectively reviewed the charts of all patients undergoing heart transplantation at our institution from July 1982 to July 1999. Data on lung cancer incidence, risk factors, treatment, and outcome were collected. Results. Five hundred seventy-two patients (mean age, 50 ± 11 years; range, 18 to 73) were considered at risk for lung cancer. Of these, 324 (57%) had a more than 20 pack-year history of smoking before transplantation. Lung cancer developed in 2 patients 1 year or less after transplantation and in 8 patients more than 1 year after transplantation (incidence, 2.2 per 1,000 patients per year of follow-up). Non-small cell lung cancer was diagnosed in all cases. Median survival was 10.8 months (range, 2 to 37.5). Routine annual chest radiographs after transplantation enabled early diagnosis in 5 cases (stages Ia and IIa), which correlated with better mean survival (28.1 months [range, 19 to 37.5] versus 5.1 months [range, 2 to 10.8]; p = 0.0002). Conclusions. The incidence of lung cancer in our population of heart transplant recipients appears to be no higher than in nontransplant populations with similar risk factors (ie, smoking and age). Routine radiographic imaging of transplant recipients may allow earlier detection of lung cancer and thus offer a survival benefit.
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U2 - 10.1016/j.athoracsur.2004.05.021
DO - 10.1016/j.athoracsur.2004.05.021
M3 - Article
C2 - 15734418
AN - SCOPUS:14244262692
SN - 0003-4975
VL - 79
SP - 980
EP - 983
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 3
ER -